Normal and Pathological Development of Melanocytes

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Team

LIONEL LARUE

Normal and Pathological Development of Melanocytes

Skin cancers and especially melanomas are constantly increasing in western countries with their incidence doubling every 12 years. Epidemiological reasons are quite clear: sun, pollution, ethnical migration and lifestyle.

Members

Journal

Scientific journal Team Larue

Seminars

Organization of meetings and conferences

Meeting participation team Larue

Seminars team Larue

Key publications

2022

CLEC12B Decreases Melanoma Proliferation by Repressing Signal Transducer and Activator of Transcription 3
Journal of Investigative Dermatology

Henri Montaudié, Laura Sormani, Bérengère Dadone-Montaudié, Marjorie Heim, Nathalie Cardot-Leccia, Meri K. Tulic, Guillaume Beranger, Anne-Sophie Gay, Delphine Debayle, Yann Cheli, Jérémy H. Raymond, Pierre Sohier, Valérie Petit, Stéphane Rocchi, Franck Gesbert, Lionel Larue, Thierry Passeron
(2022 01 Feb)
2022

Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage
Development

Sophie Colombo, Valérie Petit, Roselyne Y. Wagner, Delphine Champeval, Ichiro Yajima, Franck Gesbert, Zackie Aktary, Irwin Davidson, Véronique Delmas, Lionel Larue
(2022 15 Jan)
2021

A role for Dynlt3 in melanosome movement, distribution, acidity and transfer
Communications Biology

Zackie Aktary, Alejandro Conde-Perez, Florian Rambow, Mathilde Di Marco, François Amblard, Ilse Hurbain, Graça Raposo, Cédric Delevoye, Sylvie Coscoy, Lionel Larue
(2021 01 Dec)
2021

BRN2 is a non-canonical melanoma tumor-suppressor
Nature Communications

Michael Hamm, Pierre Sohier, Valérie Petit, Jérémy H. Raymond, Véronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Göran B. Jönsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue
(2021 01 Dec)
2021

Targeted Knockout of β-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects
Journal of Investigative Dermatology

Madeleine Le Coz, Zackie Aktary, Natsuki Watanabe, Ichiro Yajima, Marie Pouteaux, Nisamanee Charoenchon, Tsutomu Motohashi, Takahiro Kunisada, André Corvelo, Lionel Larue
(2021 01 May)
2020

Sequencing two Tyr::CreER T2 transgenic mouse lines
Pigment Cell & Melanoma Research

Zackie Aktary, Andre Corvelo, Camille Estrin, Lionel Larue
(2020 01 May)
2019

C57BL/6 congenic mouse NRAS Q61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivo
Pigment Cell & Melanoma Research

Valérie Petit, Jeremy Raymond, Christophe Alberti, Marie Pouteaux, Stuart J. Gallagher, Mai Q. Nguyen, Andrew E. Aplin, Véronique Delmas, Lionel Larue
(2019 01 Nov)
2019

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
Genes & Development

Katharine Herbert, Romuald Binet, Jean-Philippe Lambert, Pakavarin Louphrasitthiphol, Halime Kalkavan, Laura Sesma-Sanz, Carla Daniela Robles-Espinoza, Sovan Sarkar, Eda Suer, Sarah Andrews, Jagat Chauhan, Nicola D. Roberts, Mark R. Middleton, Anne-Claude Gingras, Jean-Yves Masson, Lionel Larue, Paola Falletta, Colin R. Goding
(2019 01 Mar)

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Normal and Pathological Development of Melanocytes

Unit

Skin cancers and especially melanomas are constantly increasing in western countries with their incidence doubling every 12 years. Epidemiological reasons are quite clear: sun, pollution, ethnical migration and lifestyle.