Cell migration and invasion

Team

DANIJELA MATIC VIGNJEVIC

Cell migration and invasion

We are interested in how epithelial cells interact with their microenvironment during migration in gut homeostasis and cancer invasion. We use a gut as a model system, and our strategy is to combine different models such as 3D cell cultures, tissue explants, mouse models and human samples coupled with different microscopy techniques and biophysical modeling.

Members

DANIJELA MATIC VIGNJEVIC

Team Leader

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MERYEM BAGHDADI

Permanent Researcher

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REDA BOURAS

Engineer

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COLINE HUGOT

Engineer

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NETA FELSENTHAL

Post-Doctoral Researcher

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SUZETTE LUST

Post-Doctoral Researcher

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CARLOS PEREZ GONZALEZ

Post-Doctoral Researcher

LOUISIANE PERRIN

Post-Doctoral Researcher

OLIVIER ZAJAC

Post-Doctoral Researcher

SOPHIE RICHON

Engineer assistant

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NEDA GLISOVIC

PhD Student

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FLORENCE PIASTRA-FACON

PhD Student

Past members

Denis Krndija

Post-Doctoral Researcher

Jorge Barbazan

Post-Doctoral Researcher

Andrew Clark

Post-Doctoral Researcher

Ralitza Staneva

PhD Student

Aleksandra Chikina

PhD Student

Ram Venkata Gannavarapu

PhD Student

Gehenna Lobo Guerrero Serrano

Post-Doctoral Researcher

Youmna Atieh

PhD Student

Jieun Choo

Post-Doctoral Researcher

Alexandre Glentis

PhD Student

Fabien Bertillot

PhD Student

Nadia Elkhatib

Post-Doctoral Researcher

Sara Geraldo

Post-Doctoral Researcher

Marie Schoumacer

PhD Student

Our projects

Role of fibroblasts in epithelial gut homeostasis and wound healing

Epithelial cell migration in gut homeostasis

Our projects

Role of cancer-associated fibroblasts in cancer invasion and therapy resistance

Role of macrophages in colon homeostasis

Key publications

2023

Optimized protocol for the generation of an orthotopic colon cancer mouse model and metastasis
STAR Protocols

Sophie Richon, Olivier Zajac, Carlos Perez Gonzalez, Danijela Matic Vignjevic
(2023 01 Mar)
2022

Self-generated gradients steer collective migration on viscoelastic collagen networks
Nature Materials

Andrew G. Clark, Ananyo Maitra, Cécile Jacques, Martin Bergert, Carlos Pérez-González, Anthony Simon, Luc Lederer, Alba Diz-Muñoz, Xavier Trepat, Raphaël Voituriez, Danijela Matic Vignjevic
(2022 01 Oct)
2021

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
Nature Cell Biology

Carlos Pérez-González, Gerardo Ceada, Francesco Greco, Marija Matejčić, Manuel Gómez-González, Natalia Castro, Anghara Menendez, Sohan Kale, Denis Krndija, Andrew G. Clark, Venkata Ram Gannavarapu, Adrián Álvarez-Varela, Pere Roca-Cusachs, Eduard Batlle, Danijela Matic Vignjevic, Marino Arroyo, Xavier Trepat
(2021 01 Jul)
2020

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption
Cell

Aleksandra S. Chikina, Francesca Nadalin, Mathieu Maurin, Mabel San-Roman, Thibault Thomas-Bonafos, Xin V. Li, Sonia Lameiras, Sylvain Baulande, Sandrine Henri, Bernard Malissen, Livia Lacerda Mariano, Jorge Barbazan, J. Magarian Blander, Iliyan D. Iliev, Danijela Matic Vignjevic, Ana-Maria Lennon-Duménil
(2020 01 Oct)
2019

Active cell migration is critical for steady-state epithelial turnover in the gut
Science

Denis Krndija, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard Hannezo, Danijela Matic Vignjevic
(2019 16 Aug)
2019

Cancer cells in the tumor core exhibit spatially coordinated migration patterns
Journal of Cell Science

Ralitza Staneva, Fatima El Marjou, Jorge Barbazan, Denis Krndija, Sophie Richon, Andrew Clark, Danijela Matic Vignjevic
(2019 01 Jan)
2017

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Nature Communications

Alexandros Glentis, Philipp Oertle, Pascale Mariani, Aleksandra Chikina, Fatima El Marjou, Youmna Attieh, Francois Zaccarini, Marick Lae, Damarys Loew, Florent Dingli, Philemon Sirven, Marie Schoumacher, Basile G. Gurchenkov, Marija Plodinec, Danijela Matic Vignjevic
(2017 01 Dec)