Forming a functional organism from a few stem cells is the challenge facing every embryo. The growth and early regionalization of an embryo require the precise orchestration in time and space of not only gene activity, but also a variety of post-transcriptional regulations. Understanding how the genetic programs that regulate embryo development, and in particular cell migration and morphogenesis, are encoded and regulated is a current challenge in developmental biology.
FHL3: A Scaffold Protein, Architect of the Embryonic Nervous SystemThe various signals that orchestrate the first notes of the concerto that is the nervous system are part of a very complex score! Even so, researchers from Institut Curie, CNRS, Inserm, and Université Paris-Saclay* have managed to decipher the role played by FHL3, a modulator that precisely regulates the information interpreted by the cells. Their work was published in Cell Report.30/07/2021