Dynamics of intra-cellular organization

Team

FRANCK PEREZ

Dynamics of intra-cellular organization

Our work focuses on two aspects of cellular dynamics, the Golgi apparatus in the secretory and retrograde trafficking pathways, and the regulation of microtubule dynamics. Our studies are carried out using a variety of approaches such as live cell imaging to follow and quantify intracellular trafficking or microtubule dynamics in the presence or absence of disrupting agents (e.g. siRNA, mutants, small molecules).

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Members

FRANCK PEREZ

Team Leader

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Post-Doctoral Researcher

SEVERINE DIVOUX

Research engineer

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OCTAVE JOLIOT

PhD Student

Key publications

2020

Localized Intercellular Transfer of Ephrin-As by Trans-endocytosis Enables Long-Term Signaling
Developmental Cell

José Ignacio Valenzuela, Franck Perez
(2020 01 Jan)
2019

RAB6 and microtubules restrict protein secretion to focal adhesions
Journal of Cell Biology

Lou Fourriere, Amal Kasri, Nelly Gareil, Sabine Bardin, Hugo Bousquet, David Pereira, Franck Perez, Bruno Goud, Gaelle Boncompain, Stéphanie Miserey-Lenkei
(2019 01 Jul)
2016

NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies
eLife

Sandrine Moutel, Nicolas Bery, Virginie Bernard, Laura Keller, Emilie Lemesre, Ario de Marco, Laetitia Ligat, Jean-Christophe Rain, Gilles Favre, Aurélien Olichon, Franck Perez
(2016 19 Jul)
2014

ESCRT Machinery Is Required for Plasma Membrane Repair
Science

Ana Joaquina Jimenez, Paolo Maiuri, Julie Lafaurie-Janvore, Séverine Divoux, Matthieu Piel, Franck Perez
(2014 28 Feb)
2012

Synchronization of secretory protein traffic in populations of cells
Nature Methods

Gaelle Boncompain, Severine Divoux, Nelly Gareil, Helene de Forges, Aurianne Lescure, Lynda Latreche, Valentina Mercanti, Florence Jollivet, Graça Raposo, Franck Perez
(2012 01 May)

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News

CATCHFIRE: An innovative tool to control the private lives of cells and view them via fluorescence

Researchers from Institut Curie, the CNRS, Sorbonne University and ENS-PSL have just developed an innovative molecular tool. Known as CATCHFIRE, it lets you not only control the closeness of two proteins, but also view their proximity. These multi-disciplinary efforts offer a number of applications for study of basic biological processes, but also in biomedicine, for genetic and metabolic diseases for example, or in the field of cell therapy for cancer treatment. These results are published on August 28, 2023, in Nature Methods.

06/09/2023

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Dynamics of intra-cellular organization

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