Our work focuses on two aspects of cellular dynamics, the Golgi apparatus in the secretory and retrograde trafficking pathways, and the regulation of microtubule dynamics. Our studies are carried out using a variety of approaches such as live cell imaging to follow and quantify intracellular trafficking or microtubule dynamics in the presence or absence of disrupting agents (e.g. siRNA, mutants, small molecules).
CATCHFIRE: An innovative tool to control the private lives of cells and view them via fluorescenceResearchers from Institut Curie, the CNRS, Sorbonne University and ENS-PSL have just developed an innovative molecular tool. Known as CATCHFIRE, it lets you not only control the closeness of two proteins, but also view their proximity. These multi-disciplinary efforts offer a number of applications for study of basic biological processes, but also in biomedicine, for genetic and metabolic diseases for example, or in the field of cell therapy for cancer treatment. These results are published on August 28, 2023, in Nature Methods.06/09/2023