Dynamics of intra-cellular organization

Team

FRANCK PEREZ

Dynamics of intra-cellular organization

We study intra-cellular trafficking in mammalian cells, focusing on the biosynthetic/secretory pathway and functions of the Golgi complex. For this purpose, we set up original tools to unravel the molecular mechanisms involved and to develop translational applications based on this knowledge.

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Members

FRANCK PEREZ

Team Leader

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BRUNO GOUD

Researcher Emeritus

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SEVERINE DIVOUX

Research Engineer

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Post-Doctoral Researcher

CHANDINI BHASKAR NAIDU

PhD Student

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Nos projets

publication_science_immunology_Sebastian_Amigorena

Analysis of transport flows

Physiological role of RAB6 using mouse models

Nanobodies

Translational applications

Key publications

2024

Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif
Molecular Biology of the Cell

Jason Ecard, Yen-Ling Lian, Séverine Divoux, Zelia Gouveia, Emmanuelle Vigne, Franck Perez, Gaelle Boncompain
(2024 01 Mar)
2023

A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity
Nature Methods

Sara Bottone, Octave Joliot, Zeyneb Vildan Cakil, Lina El Hajji, Louise-Marie Rakotoarison, Gaelle Boncompain, Franck Perez, Arnaud Gautier
(2023 01 Oct)
2022

RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination
EMBO reports

Jean‐Baptiste Brault, Sabine Bardin, Marusa Lampic, Jacopo A Carpentieri, Laure Coquand, Maxime Penisson, Hugo Lachuer, Guiliana Soraya Victoria, Sarah Baloul, Fatima El Marjou, Gaelle Boncompain, Stephanie Miserey‐Lenkei, Richard Belvindrah, Vincent Fraisier, Fiona Francis, Franck Perez, Bruno Goud, Alexandre D Baffet
(2022 06 Oct)
2019

Targeting CCR5 trafficking to inhibit HIV-1 infection
Science Advances

Gaelle Boncompain, Floriane Herit, Sarah Tessier, Aurianne Lescure, Elaine Del Nery, Pierre Gestraud, Isabelle Staropoli, Yuko Fukata, Masaki Fukata, Anne Brelot, Florence Niedergang, Franck Perez
(2019 11 Oct)
2019

RAB6 and microtubules restrict protein secretion to focal adhesions
Journal of Cell Biology

Lou Fourriere, Amal Kasri, Nelly Gareil, Sabine Bardin, Hugo Bousquet, David Pereira, Franck Perez, Bruno Goud, Gaelle Boncompain, Stéphanie Miserey-Lenkei
(2019 01 Jul)

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News

CATCHFIRE: An innovative tool to control the private lives of cells and view them via fluorescence

Researchers from Institut Curie, the CNRS, Sorbonne University and ENS-PSL have just developed an innovative molecular tool. Known as CATCHFIRE, it lets you not only control the closeness of two proteins, but also view their proximity. These multi-disciplinary efforts offer a number of applications for study of basic biological processes, but also in biomedicine, for genetic and metabolic diseases for example, or in the field of cell therapy for cancer treatment. These results are published on August 28, 2023, in Nature Methods.

06/09/2023

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Dynamics of intra-cellular organization

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