Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
Laboratory
The successful candidate (F/M) will join Valérie Borde's team belonging to the Institut Curie Research Center and affiliated to the Nuclear Dynamics and Dynamics of Genetic Information departments.
The Institut Curie is a highly vibrant research center, offering an international and multidisciplinary research environment in central Paris.
The Chromosome Dynamics and Recombination team led by Valérie Borde, studies the mechanisms involved in the repair of double-strand breaks during meiosis and somatic growth, combining cutting-edge genomics, proteomics and molecular biology technologies (https://institut-curie.org/team/borde). It is a highly dynamic international group currently including 2 PhD students, 1 post-doc, 4 engineers and 2 staff scientists. In addition to in-house scientific and technical skills provided by team members, the post-doctoral fellow will benefit from the stimulating and collaborative environment of the Institut Curie Research Center and from its cutting-edge technological platforms.
Recent publications:
Nicolas, Y., Bret, H., Cannavo, E., Acharya, A., Cejka, P.#, Borde, V.# and Guérois, R.# (2024) “Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.” Molecular Cell 84, 2223-2237.
Pyatnitskaya, A., Andreani, J., Guérois, R., De Muyt, A. and Borde, V. (2022) The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes and Development 36, 53-69.
Cohen, S., Guenolé, A., Lazar, I., Marnef, A., Clouaire, T., Vernekar, D., Puget, N., Rocher, V., Arnould, C., Aguirrebengoa, M., Genais, M., Firmin, N., Shamanna, R., Mourad, R., Bohr, W., Borde, V. and Legube, G. (2022) A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrids accumulation. Nature Communications 13, 2012.
The project
This exciting project will focus on the study of the molecular mechanisms of DSB repair in normal and recombination-deficient human cells at defined genomic locations to explore different genomic contexts. The post-doc will use innovative unpublished genomic approaches in combination with genetic, molecular and genome editing approaches. The project will be made with the support from Institut Curie genomic facilities, and from an engineer in the lab for computational analyses.
Training and Skills required
- Training: We invite applications from candidates with a strong interest in DNA repair and chromosome biology, and a strong experience in manipulating human cell lines. Ideally (but not mandatory) with a mixed background in molecular biology and computational analyses of genomic data.
- Scientific skills: Candidates holding, or shortly expecting to be awarded, a PhD degree in related fields are encouraged to apply.
- Applicants should have at least one publication as first author.
- Language skills: Candidates should be fluent in English, which is the language used in the lab.
Abilities
- Highly self-motivated
- Rigorous
- Creativity, ability to work independently and to collaborate with others
All our opportunities are open to people with disabilities
Contract information
Type of contract: Fixed-term contract.
Starting date: from October 15th 2025
Duration: initial 12 months will be provided but the candidate should be competitive to apply for postdoctoral fellowships.
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Reference:
Contact
Please send your CV, letter of motivation and 2 references to
Publication date: 31/07/2025
Deadline for application: until filled
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf