We study the process of recombination, that ensures genome stability and faithful chromosome segregation, during the production of haploid gametes at meiosis. Homologous recombination takes place when a broken or damaged chromosome uses a homologous sequence as a template for repair. Defects in homologous recombination have severe consequences and are linked to several disorders, such as certain inherited cancers and genetic instability syndromes.
Meiosis and crossing over: pairing and separatingAt Institut Curie, the “Chromosome Dynamics and Recombination” team headed by Valérie Borde, CNRS research director, identified the molecularbases of this mechanism – during meiosis - involving pairing and recombination of homologous chromosomes, using the Saccharomyces cerevisiae yeast model. This study is published in the journal Genes and Development.05/01/2022
Meiosis and DNA repair: researchers decipher the activity of a specific molecular complexResearchers from I2BC/CEA-Joliot in collaboration with a team from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis of a "molecular scissors" mechanism involved in DNA repair during meiosis - the step leading to the formation of gametes.08/06/2021
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