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Chromosome Dynamics and Recombination

We study the process of recombination, that ensures genome stability and faithful chromosome segregation, during the production of haploid gametes at meiosis. Homologous recombination takes place when a broken or damaged chromosome uses a homologous sequence as a template for repair. Defects in homologous recombination have severe consequences and are linked to several disorders, such as certain inherited cancers and genetic instability syndromes.

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