Team
Chromosome Dynamics and Recombination
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Team
VALERIE BORDE
Chromosome Dynamics and Recombination
We study the process of recombination, that ensures genome stability and faithful chromosome segregation, during the production of haploid gametes at meiosis. Homologous recombination takes place when a broken or damaged chromosome uses a homologous sequence as a template for repair. Defects in homologous recombination have severe consequences and are linked to several disorders, such as certain inherited cancers and genetic instability syndromes.
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Key publications
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Absence of chromosome axis protein recruitment prevents meiotic recombination chromosome-wide in the budding yeast Lachancea kluyveriProceedings of the National Academy of Sciences
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The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assemblyGenes & Development
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Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
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Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formationProceedings of the National Academy of Sciences
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News
All news
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Drs. Allison Bardin and Valérie Borde elected members of the European EMBO organizationTo mark its 60th anniversary, the European Molecular Biology Organization (EMBO) has unveiled its 100 new members. Among them are nine French researchers, including Drs. Allison Bardin and Valérie Borde, team leaders at Institut Curie Research Center. Their mission: to promote the life sciences, guide strategic research choices and encourage the emergence of a new generation of excellent researchers.09/07/2024 -
DNA recombination: AlphaFold2 breaks a lockIn a study published in Molecular Cell, teams from I2BC, the team Chromosome Dynamics and Recombination (CNRS UMR 3244 / Sorbonne Université) at Institut Curie, led by the Dr Valérie Borde in collaboration with teams from the I2BC (CEA) and the IRB (University of Italian Switzerland) shed light on how the human nuclease MRN works. Structural predictions obtained with AlphaFold2 and confirmed by in vitro and in vivo experiments show that the phosphorylated Sae2/CtIP protein forms a network of interactions with MRN that favours the removal of its autoinhibition.03/07/2024 -
Meiosis and crossing over: pairing and separatingAt Institut Curie, the “Chromosome Dynamics and Recombination” team headed by Valérie Borde, CNRS research director, identified the molecularbases of this mechanism – during meiosis - involving pairing and recombination of homologous chromosomes, using the Saccharomyces cerevisiae yeast model. This study is published in the journal Genes and Development.05/01/2022 -
Meiosis and DNA repair: researchers decipher the activity of a specific molecular complexResearchers from I2BC/CEA-Joliot in collaboration with a team from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis of a "molecular scissors" mechanism involved in DNA repair during meiosis - the step leading to the formation of gametes.08/06/2021