Team
Chromosome Dynamics and Recombination
Thematic areas of research:
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Team
VALERIE BORDE
Chromosome Dynamics and Recombination
We study the process of recombination, that ensures genome stability and faithful chromosome segregation, during the production of haploid gametes at meiosis. Homologous recombination takes place when a broken or damaged chromosome uses a homologous sequence as a template for repair. Defects in homologous recombination have severe consequences and are linked to several disorders, such as certain inherited cancers and genetic instability syndromes.
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Key publications
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The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assemblyGenes & Development
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Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
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Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formationProceedings of the National Academy of Sciences
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News
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Meiosis and crossing over: pairing and separatingAt Institut Curie, the “Chromosome Dynamics and Recombination” team headed by Valérie Borde, CNRS research director, identified the molecularbases of this mechanism – during meiosis - involving pairing and recombination of homologous chromosomes, using the Saccharomyces cerevisiae yeast model. This study is published in the journal Genes and Development.05/01/2022 -
Meiosis and DNA repair: researchers decipher the activity of a specific molecular complexResearchers from I2BC/CEA-Joliot in collaboration with a team from Institut Curie and IRCM/CEA-Jacob, lay the molecular basis of a "molecular scissors" mechanism involved in DNA repair during meiosis - the step leading to the formation of gametes.08/06/2021