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Chromosome Dynamics and Recombination

We study the process of recombination, that ensures genome stability and faithful chromosome segregation, during the production of haploid gametes at meiosis. Homologous recombination takes place when a broken or damaged chromosome uses a homologous sequence as a template for repair. Defects in homologous recombination have severe consequences and are linked to several disorders, such as certain inherited cancers and genetic instability syndromes.

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  • Image microscopique Tétrades de levures S. cerevisiae produites après la méiose.
    Meiosis and crossing over: pairing and separating
    At Institut Curie, the “Chromosome Dynamics and Recombination” team headed by Valérie Borde, CNRS research director, identified the molecularbases of this mechanism – during meiosis - involving pairing and recombination of homologous chromosomes, using the Saccharomyces cerevisiae yeast model. This study is published in the journal Genes and Development.
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Job offers
  • Postdoctoral Position in Homologous Recombination (M/F)
    Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
    The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

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