VINCENT PENNANEACH

DNA replication and repair occurs in the context of DNA packaged into chromatin. Flaws in the DNA replication process, known as replication stress, result in inaccurate chromosome duplication and mitotic abnormalities, promoting genome and epigenome instability contributing to tumorigenesis.

We are interested in understanding how Homologous recombination (HR), a DNA repair mechanism acting as a tumor suppressor pathway, plays a crucial role in the recovery of dysfunctional forks.