Research Director Inserm
Recherche - Paris
Spécialités / domaines
Translational research
Functions within Institut Curie:

Dr. E. Piaggio is a clinical biologist and a doctor of immunology. Currently she is research director of INSERM and leads the team "Translational Immunotherapy" at INSERM unit 932 "Immunity and cancer", at the Institut Curie in Paris. Her career has been focused on immunotherapy based on regulatory T lymphocytes, applied to infectious diseases, autoimmunity, aloreactivity and more recently, cancer. Her team is interested in the study of the draining lymph nodes of human tumors and in the development of new immunotherapies translatable to patients. She iscurrently  working on the following four themes:
- A translational approach to optimize anti-tumor immune responses in rhabdoid cancers.
- The study of the biology and functionality of tumor regulatory T cells.
- Design and study of the functionality of IL-2 variants allowing the specific inhibition of tumor regulatory T cells
- Study of the immune response of T cells induced by tumor neoantigens in three types of cancers (breast, head and neck and melanoma)

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial
Nature Cancer
Stephen J. Bagley, Zev A. Binder, Lamia Lamrani, Eliana Marinari, Arati S. Desai, MacLean P. Nasrallah, Eileen Maloney, Steven Brem, Robert A. Lustig, Goldie Kurtz, Michelle Alonso-Basanta, Pierre-Emmanuel Bonté, Christel Goudot, Wilfrid Richer, Eliane Piaggio, Shawn Kothari, Lea Guyonnet, Coralie L. Guerin, Joshua J. Waterfall, Suyash Mohan, Wei-Ting Hwang, Oliver Y. Tang, Meghan Logun, Meghna Bhattacharyya, Kelly Markowitz, Devora Delman, Amy Marshall, E. John Wherry, Sebastian Amigorena, Gregory L. Beatty, Jennifer L. Brogdon, Elizabeth Hexner, Denis Migliorini, Cecile Alanio, Donald M. O’Rourke
CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas
Nature Communications
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer
Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Yohan Gerber-Ferder, Christian P. Bromley, Mattia Bugatti, Nicolas Gonzalo Núñez, Jimena Tosello Boari, Wilfrid Richer, Laurie Menger, Jordan Denizeau, Christine Sedlik, Pamela Caudana, Fiorella Kotsias, Leticia L. Niborski, Sophie Viel, Mylène Bohec, Sonia Lameiras, Sylvain Baulande, Laëtitia Lesage, André Nicolas, Didier Meseure, Anne Vincent-Salomon, Fabien Reyal, Charles-Antoine Dutertre, Florent Ginhoux, Lene Vimeux, Emmanuel Donnadieu, Bénédicte Buttard, Jérôme Galon, Santiago Zelenay, William Vermi, Pierre Guermonprez, Eliane Piaggio, Julie Helft
Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination
Clinical & Translational Immunology
Rodrigo Nalio Ramos, Caroline Tosch, Fiorella Kotsias, Marie‐Christine Claudepierre, Doris Schmitt, Christelle Remy‐Ziller, Chantal Hoffmann, Marine Ricordel, Virginie Nourtier, Isabelle Farine, Laurence Laruelle, Julie Hortelano, Clementine Spring‐Giusti, Christine Sedlik, Christophe Le Tourneau, Caroline Hoffmann, Nathalie Silvestre, Philippe Erbs, Kaidre Bendjama, Christine Thioudellet, Eric Quemeneur, Eliane Piaggio, Karola Rittner
Prognostic value of intratumoral Fusobacterium nucleatum and association with immune-related gene expression in oral squamous cell carcinoma patients
Scientific Reports
Cindy Neuzillet, Manon Marchais, Sophie Vacher, Marc Hilmi, Anne Schnitzler, Didier Meseure, Renaud Leclere, Charlotte Lecerf, Coraline Dubot, Emmanuelle Jeannot, Jerzy Klijanienko, Odette Mariani, Valentin Calugaru, Caroline Hoffmann, Maria Lesnik, Nathalie Badois, Edith Borcoman, Eliane Piaggio, Maud Kamal, Christophe Le Tourneau, Ivan Bieche
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Journal of Experimental Medicine
Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour, Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli, Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune, Franck Letourneur, Gwennhael Autret, Patrick S.C. Leung, M. Eric Gershwin, Jie S. Zhu, Mark J. Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim, Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel, Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri, Guido Kroemer, Jonathan G. Pol
Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients
Frontiers in Immunology
Maria C. Ramello, Nicolás G. Núñez, Jimena Tosello Boari, Sabrina N. Bossio, Fernando P. Canale, Carolina Abrate, Nicolas Ponce, Andrés Del Castillo, Marta Ledesma, Sophie Viel, Wilfrid Richer, Christine Sedlik, Carolina Tiraboschi, Marcos Muñoz, Daniel Compagno, Adriana Gruppi, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Developmental bifurcation of human T follicular regulatory cells
Science Immunology
Saumya Kumar, Válter R. Fonseca, Filipa Ribeiro, Afonso P. Basto, Ana Água-Doce, Marta Monteiro, Dikélélé Elessa, Ricardo J. Miragaia, Tomás Gomes, Eliane Piaggio, Elodie Segura, Margarida Gama-Carvalho, Sarah A. Teichmann, Luis Graca