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Team
ELIANE PIAGGIO
Translational immunotherapy

Cancer immunotherapy is revolutionizing cancer treatment. Until now, treatments were aimed at tumor cells. Today, immunotherapy targets the patient's immune system to allow it to eradicate the tumor specifically and over the long term.

Key publications
  • Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer
    Cell
    Rodrigo Nalio Ramos, Yoann Missolo-Koussou, Yohan Gerber-Ferder, Christian P. Bromley, Mattia Bugatti, Nicolas Gonzalo Núñez, Jimena Tosello Boari, Wilfrid Richer, Laurie Menger, Jordan Denizeau, Christine Sedlik, Pamela Caudana, Fiorella Kotsias, Leticia L. Niborski, Sophie Viel, Mylène Bohec, Sonia Lameiras, Sylvain Baulande, Laëtitia Lesage, André Nicolas, Didier Meseure, Anne Vincent-Salomon, Fabien Reyal, Charles-Antoine Dutertre, Florent Ginhoux, Lene Vimeux, Emmanuel Donnadieu, Bénédicte Buttard, Jérôme Galon, Santiago Zelenay, William Vermi, Pierre Guermonprez, Eliane Piaggio, Julie Helft
  • Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
    Nature Communications
    Nicolas Gonzalo Núñez, Jimena Tosello Boari, Rodrigo Nalio Ramos, Wilfrid Richer, Nicolas Cagnard, Cyrill Dimitri Anderfuhren, Leticia Laura Niborski, Jeremy Bigot, Didier Meseure, Philippe De La Rochere, Maud Milder, Sophie Viel, Delphine Loirat, Louis Pérol, Anne Vincent-Salomon, Xavier Sastre-Garau, Becher Burkhard, Christine Sedlik, Olivier Lantz, Sebastian Amigorena, Eliane Piaggio
  • Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
    Cancer Cell
    Amaury Leruste, Jimena Tosello, Rodrigo Nalio Ramos, Arnault Tauziède-Espariat, Solène Brohard, Zhi-Yan Han, Kevin Beccaria, Mamy Andrianteranagna, Pamela Caudana, Jovan Nikolic, Céline Chauvin, Leticia Laura Niborski, Valeria Manriquez, Wilfrid Richer, Julien Masliah-Planchon, Sandrine Grossetête-Lalami, Mylene Bohec, Sonia Lameiras, Sylvain Baulande, Celio Pouponnot, Aurore Coulomb, Louise Galmiche, Didier Surdez, Nicolas Servant, Julie Helft, Christine Sedlik, Stéphanie Puget, Philippe Benaroch, Olivier Delattre, Joshua J. Waterfall, Eliane Piaggio, Franck Bourdeaut
  • Loss of immune tolerance to IL-2 in type 1 diabetes
    Nature Communications
    Louis Pérol, John M. Lindner, Pamela Caudana, Nicolas Gonzalo Nunez, Audrey Baeyens, Andrea Valle, Christine Sedlik, Delphine Loirat, Olivier Boyer, Alain Créange, José Laurent Cohen, Ute Christine Rogner, Jun Yamanouchi, Martine Marchant, Xavier Charles Leber, Meike Scharenberg, Marie-Claude Gagnerault, Roberto Mallone, Manuela Battaglia, Pere Santamaria, Agnès Hartemann, Elisabetta Traggiai, Eliane Piaggio
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News
  • Immunofluorescence sur une tumeur mammaire
    Macrophage populations in breast cancer
    In contrast to the current consensus, the presence of macrophages around breast cancer is not necessarily a bad sign, according to the work conducted by Eliane Piaggio’s Translational Immunotherapy team at Institut Curie. Biologists reveal a new population of macrophages that is associated to better prognosis for breast cancer patients. These results were published in the journal Cell on March 23, 2022.
    30/03/2022
  • Egle Tx
    Une nouvelle stratégie en immunothérapie : l’Institut Curie salue la levée de fonds de sa spin-off Egle Therapeutics
    Créée en 2020, la société Egle Therapeutics vient de lever 40 millions d’euros majoritairement apportés par LSP et Bpifrance, via son fonds InnoBio 2, ainsi que Fund+, Bioqube Ventures et Takeda Ventures Inc. Spin-off de l’Institut Curie, cette société de biotechnologie est pionnière en matière d’immunomodulation des lymphocytes T régulateurs, appliquée à l'oncologie et aux maladies auto-immunes. Les fonds seront utilisés afin d’accélérer son développement pour de futures applications cliniques.
    19/10/2021
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