Recherche - Paris
Spécialités / domaines
Cell biology,
Molecular biology,
Translational research,
Single Cell
Functions within Institut Curie:

Since 2017, in the laboratory of Céline Vallot, I am working on chemotolerance in triple negative breast cancer. We demonstrated that the repressive histone mark H3K27me3 is a determinant of cell fate at the onset of chemotherapy exposure, monitoring epigenomes, transcriptomes and lineages with single-cell resolution. We show that the persister expression program is primed with both H3K4me3 and H3K27me3 in unchallenged cells, H3K27me3 being the lock to its transcriptional activation. We further establish that H3K27me3 controls cell fate upon chemotherapy exposure. Our results highlight how chromatin landscapes shape the potential of cancer cells to respond to initial therapeutic insult.

H3K27me3 is a determinant of chemotolerance in triple-negative breast cancer
Justine Marsolier, Pacôme Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Léa Baudre, Kevin Grosselin, Mylène Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouzé, Elisabetta Marangoni, Leïla Perié, Céline Vallot