Dynamics of epigenetic plasticity in cancer

 To understand epigenetic aberrations in tumor progression, there are few cellular or animal models compared to genetic alterations. This discrepancy is large due to the plasticity of epigenetic modifications. Inducing a desired epigenetic modification at  a given location in the genome remains a challenge. In the team, we seek to understand the dynamics of acquisition of epigenetic alterations during tumorigenesis, to evaluate their stability over time and to characterize their link with the tumor phenotype. These questions are prerequisites for using these alterations as therapeutic targets.