Dynamics of epigenetic plasticity in cancer

Considerable data have been accumulated across the past decades on the role of mutations in cancer. However, while a number of genetic mechanisms driving tumor progression or resistance processes has been discovered, in many cases genetic mechanisms driving these processes cannot be found, raising the possibility of non-genetic plasticity or rare cell variability. Hence, besides genetic mechanisms, mounting efforts now concentrate on non-genetic and particularly epigenetic mechanisms that may account for the adaptability of cancer cells to environmental, metabolic or therapy-related stresses. In the lab, we focus on the study of chromatin landscapes, and develop approaches to study the heterogeneity and dynamics of chromatin landscapes at single-cell resolution both in vitro and in vivo in breast cancer. Our goal is to reveal the timing of occurrence of chromatin alterations, address their stability over time, and their association to the cellular phenotype.




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Interactive analysis of single-cell epigenomic landscapes with ChromSCapeNature Communications
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Institut Curie’s latest progress at the AACR Annual Meeting 2023From April 14 to 19, 2023, in Orlando, USA, the international scientific and medical community comes together for the annual meeting of the American Association for Cancer Research, an opportunity for scientists from Institut Curie to present their findings in various fields of cancer research.17/04/2023
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Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023
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Céline Vallot, médaille de l'innovation 2022 du CNRSLa médaille de l’innovation 2022 du CNRS a été remise le 16 juin 2022 par Sylvie Retailleau, ministre de l'Enseignement supérieur et de la Recherche, et Antoine Petit, président-directeur général du CNRS à Céline Vallot, biologiste et cheffe d’équipe au Centre de recherche de l’Institut Curie.16/06/2022
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Epigenetic treatments: New allies for chemotherapies?Though chemotherapies are effective in some patients, tumour cells may acquire tolerance to these treatments. In other words, cells adapt to chemotherapy so they can survive.04/05/2022
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Yolanda Prezado, Carsten Janke, Céline Vallot et Nicolas Manel récompensés par l’Académie des sciencesLe 23 novembre, l’Académie des sciences a remis, lors d'une cérémonie exceptionnelle sous la coupole de l’Institut de France, l’ensemble des prix et médailles qu’elle a attribués en 2021. Quatre chercheurs et médecins de l’Institut Curie ont été distingués. Toutes nos félicitations !25/11/2021