NADEGE GRUEL

Doctor

Recherche - Paris

Spécialités / domaines

Recombinant antibodies,

Integrative tumor biology, immunology and environment,

Molecular biology,

Cancer,

Genomics,

Single Cell,

Sequencing

Functions within Institut Curie:

Research Engineer

Diversity and Plasticity of Chilhood Tumors (DePiCT)
Unit : Cancer, Heterogeneity, Instability and Plasticity - CHIP (U830)

Cancer, Heterogeneity, Instability and Plasticity - CHIP (U830)

Présentation

With a double specialization, (immunology, master 2 and genetics, master 2 + PhD), I have always worked in laboratories at the research-clinical interface (antibody biotechnology, molecular characterization of breast cancer, intratumoral heterogeneity of sarcomas), often in pairs with doctors from the institute. These different missions showed my adaptability and the extent of my theoretical knowledge (from immunology to genetics) and techniques (analysis on single cells).

Publications

2023

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Nature Communications

Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt Bhalshankar, Angel M. Carcaboso, Birgit Geoerger, Hermann Rohrer, Didier Surdez, Valentina Boeva, Gudrun Schleiermacher, Olivier Delattre, Isabelle Janoueix-Lerosey

(2023 04 May)

2022

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma

Journal for ImmunoTherapy of Cancer

Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoerger, Fatima Mechta-Grigoriou, Gudrun Schleiermacher, Laurie Menger, Olivier Delattre, Isabelle Janoueix-Lerosey

(2022 01 Aug)

2022

Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions

Molecular Cell

Julien Vibert, Olivier Saulnier, Céline Collin, Floriane Petit, Kyra J.E. Borgman, Jérômine Vigneau, Maud Gautier, Sakina Zaidi, Gaëlle Pierron, Sarah Watson, Nadège Gruel, Clémence Hénon, Sophie Postel-Vinay, Marc Deloger, Virginie Raynal, Sylvain Baulande, Karine Laud-Duval, Véronique Hill, Sandrine Grossetête, Florent Dingli, Damarys Loew, Jacob Torrejon, Olivier Ayrault, Martin F. Orth, Thomas G.P. Grünewald, Didier Surdez, Antoine Coulon, Joshua J. Waterfall, Olivier Delattre

(2022 01 Jul)

2021

Identification of Tissue of Origin and Guided Therapeutic Applications in Cancers of Unknown Primary Using Deep Learning and RNA Sequencing (TransCUPtomics)

The Journal of Molecular Diagnostics

Julien Vibert, Gaëlle Pierron, Camille Benoist, Nadège Gruel, Delphine Guillemot, Anne Vincent-Salomon, Christophe Le Tourneau, Alain Livartowski, Odette Mariani, Sylvain Baulande, François-Clément Bidard, Olivier Delattre, Joshua J. Waterfall, Sarah Watson

(2021 01 Oct)

2021

1531P Multi-omic characterization of dedifferentiated liposarcoma: Towards a new model of oncogenesis?

Annals of Oncology

S. Watson, N. Gruel, J. Vibert, S. Bonvalot, S. El Zein, D. Tzanis, S. Lameiras, E. Girard, M. Galut, M. Lavigne, O. Mariani, S. Baulande, O. Delattre, J. Waterfall

(2021 01 Sep)

2021

Neoadjuvant Everolimus for Adult Giant Mesenteric Cystic Lymphangioma with mTOR Pathway Activation

The Oncologist

Sophie El Zein, Nadège Gruel, Sylvie Bonvalot, Olivier Mir, Sarah Watson

(2021 01 Jul)

2021

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Journal for ImmunoTherapy of Cancer

Soumaya Karaki, Charlotte Blanc, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Estelle Dransart, Marie Anson, Corinne Tanchot, Lea Paolini, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Nadine Benhamouda, Cecile Badoual, Diane Damotte, Emmanuel Donnadieu, Sebastian Kobold, Fathia Mami-Chouaib, Rachel Golub, Ludger Johannes, Eric Tartour

(2021 01 Mar)

2020

Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution

Cell Reports

Marie-Ming Aynaud, Olivier Mirabeau, Nadege Gruel, Sandrine Grossetête, Valentina Boeva, Simon Durand, Didier Surdez, Olivier Saulnier, Sakina Zaïdi, Svetlana Gribkova, Aziz Fouché, Ulykbek Kairov, Virginie Raynal, Franck Tirode, Thomas G.P. Grünewald, Mylene Bohec, Sylvain Baulande, Isabelle Janoueix-Lerosey, Jean-Philippe Vert, Emmanuel Barillot, Olivier Delattre, Andrei Zinovyev

(2020 01 Feb)

2018

Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression

The American Journal of Pathology

Pierre Romero, Vanessa Benhamo, Gabrielle Deniziaut, Laetitia Fuhrmann, Frédérique Berger, Elodie Manié, Jaydutt Bhalshankar, Sophie Vacher, Cécile Laurent, Elisabetta Marangoni, Nadège Gruel, Gaëtan MacGrogan, Roman Rouzier, Olivier Delattre, Tatiana Popova, Fabien Reyal, Marc-Henri Stern, Dominique Stoppa-Lyonnet, Caterina Marchiò, Ivan Bièche, Anne Vincent-Salomon

(2018 01 Oct)

2016

LIN7A is a major determinant of cell-polarity defects in breast carcinomas

Breast Cancer Research

Nadège Gruel, Laetitia Fuhrmann, Catalina Lodillinsky, Vanessa Benhamo, Odette Mariani, Aurélie Cédenot, Laurent Arnould, Gaëtan Macgrogan, Xavier Sastre-Garau, Philippe Chavrier, Olivier Delattre, Anne Vincent-Salomon

(2016 01 Dec)