PHILIPPE CHAVRIER

Doctor,

Research Director CNRS

Recherche - Paris

Spécialités / domaines

Multi-scale physics-chemistry-biology and cancer (molecules, cells, tissues and organisms)

Functions within Institut Curie:

Team Leader

Membrane and Cytoskeleton Dynamics
Unit : Cell Biology and Cancer (UMR144)

Publications

2023

A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion

Nature Cell Biology

Pedro Monteiro, David Remy, Eline Lemerle, Fiona Routet, Anne-Sophie Macé, Chloé Guedj, Benoit Ladoux, Stéphane Vassilopoulos, Christophe Lamaze, Philippe Chavrier

(2023 01 Dec)

2023

Multiscale model of the different modes of cancer cell invasion

Bioinformatics

Marco Ruscone, Arnau Montagud, Philippe Chavrier, Olivier Destaing, Isabelle Bonnet, Andrei Zinovyev, Emmanuel Barillot, Vincent Noël, Laurence Calzone

(2023 01 Jun)

2021

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Cell

Guilherme Pedreira de Freitas Nader, Sonia Agüera-Gonzalez, Fiona Routet, Matthieu Gratia, Mathieu Maurin, Valeria Cancila, Clotilde Cadart, Andrea Palamidessi, Rodrigo Nalio Ramos, Mabel San Roman, Matteo Gentili, Ayako Yamada, Alice Williart, Catalina Lodillinsky, Emilie Lagoutte, Catherine Villard, Jean-Louis Viovy, Claudio Tripodo, Jérôme Galon, Giorgio Scita, Nicolas Manel, Philippe Chavrier, Matthieu Piel

(2021 01 Sep)

2021

mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1‐MMP Endocytosis Arrest

Advanced Science

Cecilia Colombero, David Remy, Sandra Antoine‐Bally, Anne‐Sophie Macé, Pedro Monteiro, Nadia ElKhatib, Margot Fournier, Ahmed Dahmani, Elodie Montaudon, Guillaume Montagnac, Elisabetta Marangoni, Philippe Chavrier

(2021 01 Sep)

2021

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Oncogene

Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Hélène Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bièche, Marie-Lise Lacombe, Ana Maria Eiján, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan

(2021 10 Jun)

2020

Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia

Journal of Cell Biology

Anna Zagryazhskaya-Masson, Pedro Monteiro, Anne-Sophie Macé, Alessia Castagnino, Robin Ferrari, Elvira Infante, Aléria Duperray-Susini, Florent Dingli, Arpad Lanyi, Damarys Loew, Elisabeth Génot, Philippe Chavrier

(2020 07 Sep)

2020

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Journal of Cell Biology

Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg

(2020 03 Aug)

2020

A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing

Journal of Cell Science

Emilie Lagoutte, Clémentine Villeneuve, Vincent Fraisier, Denis Krndija, Marie-Ange Deugnier, Philippe Chavrier, Carine Rossé

(2020 15 Jun)

2019

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

Nature Communications

Robin Ferrari, Gaëlle Martin, Oya Tagit, Alan Guichard, Alessandra Cambi, Raphaël Voituriez, Stéphane Vassilopoulos, Philippe Chavrier

(2019 01 Dec)

2019

aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions

Proceedings of the National Academy of Sciences

Clémentine Villeneuve, Emilie Lagoutte, Ludmilla de Plater, Samuel Mathieu, Jean-Baptiste Manneville, Jean-Léon Maître, Philippe Chavrier, Carine Rossé

(2019 26 Nov)

Actualites

World Triple Negative Breast Cancer Day: innovation to cure more women