ROSINE ONCLERCQ-DELIC

Doctor,

CNRS

Recherche - Orsay

Spécialités / domaines

In vivo experiment,

Cell biology,

Molecular biology

Functions within Institut Curie:

Research Engineer

Controlling Microtubule Dynamics and Function with the tubulin code
Unit : Genome Integrity, RNA and Cancer (UMR3348)

Présentation

-Member of the Animal Welfare Ethics Committee of the Curie Institute and the Animal Welfare Structure since its creation.

-CNRS research engineer at the Curie Institute since 2004 (UMR CNRS 2027 then 3348), in the team of Mounira Amor-Guéret.

-Person competent in radiation protection at the Orsay site until 2017

Publications

2023

Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors

Cancer Letters

Rosine Onclercq-Delic, Géraldine Buhagiar-Labarchède, Sophie Leboucher, Thibaut Larcher, Mireille Ledevin, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret

(2023 01 Feb)

2022

Cytidine deaminase activity increases in the blood of breast cancer patients

Scientific Reports

Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Sophie Vacher, Frédérique Berger, Ivan Bièche, Dominique Stoppa-Lyonnet, Mounira Amor-Guéret

(2022 18 Aug)

2022

Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels

Cellular and Molecular Life Sciences

Hamza Mameri, Géraldine Buhagiar-Labarchède, Gaëlle Fontaine, Céline Corcelle, Caroline Barette, Rosine Onclercq-Delic, Claire Beauvineau, Florence Mahuteau-Betzer, Mounira Amor-Guéret

(2022 01 Aug)

2020

A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD+

Scientific Reports

Sandra Cunha Silveira, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret

(2020 01 Dec)

2020

Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms

Open Biology

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Gaëlle Fontaine, Sarah Lambert, Mounira Amor-Guéret

(2020 01 May)

2017

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

Nature Communications

Elias Bou Samra, Géraldine Buhagiar-Labarchède, Christelle Machon, Jérôme Guitton, Rosine Onclercq-Delic, Michael R. Green, Olivier Alibert, Claude Gazin, Xavier Veaute, Mounira Amor-Guéret

(2017 01 Dec)

2017

Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity

Cell Cycle

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Christian Jaulin, Mounira Amor-Guéret

(2017 03 Jun)

2017

Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against Cancer

Clinical Cancer Research

Hamza Mameri, Ivan Bièche, Didier Meseure, Elisabetta Marangoni, Géraldine Buhagiar-Labarchède, André Nicolas, Sophie Vacher, Rosine Onclercq-Delic, Vinodh Rajapakse, Sudhir Varma, William C. Reinhold, Yves Pommier, Mounira Amor-Guéret

(2017 15 Apr)

2016

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation

Journal of Cell Science

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Denis Biard, Sarah Lambert, Mounira Amor-Guéret

(2016 01 Jan)

2015

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA

PLOS Genetics

Simon Gemble, Akshay Ahuja, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Julien Dairou, Denis S. F. Biard, Sarah Lambert, Massimo Lopes, Mounira Amor-Guéret

(2015 16 Jul)