SOPHIE BOMBARD

Doctor

Recherche - Orsay

Spécialités / domaines

Biologie et chimie des radiations, signalisation cellulaire et cancer

Functions within Institut Curie:

Permanent Researcher

Drugs and probes for Nucleic acids secondary structures
Unit : Chemistry and Modelling for Biology of Cancer (UMR9187 / U1196)

Publications

2024

A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome

Journal of Biomedical Science

Keli Kuang, Chunyan Li, Fatlinda Maksut, Deepanjan Ghosh, Robin Vinck, Maolin Wang, Joël Poupon, Run Xiang, Wen Li, Fei Li, Zhu Wang, Junrong Du, Marie-Paule Teulade-Fichou, Gilles Gasser, Sophie Bombard, Tao Jia

(2024 13 May)

2024

Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer

ChemBioChem

Chloé Breton-Patient, Sébastien Billotte, Patricia Duchambon, Gaëlle Fontaine, Sophie Bombard, Sandrine Piguel

(2024 16 Feb)

2023

Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts

Nucleic Acids Research

Eka Putra Gusti Ngurah Putu, Laurent Cattiaux, Thomas Lavergne, Yves Pommier, Sophie Bombard, Anton Granzhan

(2023 18 Oct)

2023

Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (<i>N</i>-Heterocyclic Carbene)-Amine-Pt(II) Complexes

Journal of Medicinal Chemistry

Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joël Poupon, Jérôme Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-François Betzer, Angela Marinetti, Sophie Bombard

(2023 16 May)

2022

Photoactivatable V‐Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G‐quadruplex Alkylating Agents

Chemistry – A European Journal

Alberto Lena, Alessandra Benassi, Michele Stasi, Christine Saint-Pierre, Mauro Freccero, Didier Gasparutto, Sophie Bombard, Filippo Doria, Daniela Verga

(2022 21 Jun)

2022

Acridine–O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity

European Journal of Medicinal Chemistry

Jaime Franco Pinto, Alexandra Fillion, Patricia Duchambon, Sophie Bombard, Anton Granzhan

(2022 01 Jan)

2021

Photoactivatable Small‐Molecule Inhibitors for Light‐Controlled TAM Kinase Activity

ChemPhotoChem

Julie Le Bescont, Liliane Mouawad, Thomas Boddaert, Sophie Bombard, Sandrine Piguel

(2021 01 Nov)

2021

Pt-ttpy, a G-quadruplex binding platinum complex, induces telomere dysfunction and G-rich regions DNA damage

Metallomics

Samar Ali, Emilia Puig Lombardi, Deepanjan Ghosh, Tao Jia, Géraldine Vitry, Lina Saker, Joël Poupon, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londono-Vallejo, Sophie Bombard

(2021 12 Jun)

2020

Nucleolin Discriminates Drastically between Long-Loop and Short-Loop Quadruplexes

Biochemistry

Abhijit Saha, Patricia Duchambon, Vanessa Masson, Damarys Loew, Sophie Bombard, Marie-Paule Teulade-Fichou

(2020 31 Mar)

2019

Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand–DNA Adducts

Chemistry – A European Journal

Coralie Caron, Xuan N. T. Duong, Régis Guillot, Sophie Bombard, Anton Granzhan

(2019 06 Feb)