During development, the formation of functional tissues and organs entails both tissue shaping (morphogenesis) and cell proliferation; two processes driven by biochemical and mechanical regulation. In toto imaging of embryos highlighted the spatial and temporal coordination between these two processes: from the earliest stage of embryonic development, to later stages during which the collective dynamics of thousands of dividing and moving cells promote the emergence of tissues and organs.
Cell division and cell geometryThe mystery of reshaping of dividing epithelial cells’ cytoskeleton has mobilized the team led by Yohanns Bellaïche at Institut Curie’s Research Center. The results of their study, describing the essential role of small enzyme proteins - RhoGTPases - on the actomyosin cytoskeleton, have just been published in the journal Current Biology. A step towards better understanding of the process controlling the number of cells and the integrity of their genomes.17/03/2023
Morphogenesis: when genetics and mechanics work togetherThe spatial distribution of cells during embryonic development of an organism (morphogenesis) is affected in many diseases, including cancer. Yohanns Bellaïche and his Polarity, Division and Morphogenesis team at Institut Curie’s Research Center, in collaboration with a laboratory from Université Paris Cité, have just revealed a new mechanism involving tissue curvature and tension, controlled by genetics. Their results have just been published in the journal Nature Communications.13/03/2023
Les clés du contrôle de l’expression génétique révélées au grand jourL’étude de la fonction des gènes au cours du développement et de l’apparition de pathologies repose sur le contrôle précis de leur expression. Si le contrôle par la lumière reste le plus efficace, il présente néanmoins quelques limitations, aujourd’hui surmontées par un système unique développé à l'Institut Curie.06/12/2021