Unit
Genetics and Developmental Biology (UMR3215 / U934)
Thematic areas of research:
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Unit
PIERRE LEOPOLD / YOHANNS BELLAICHE
Genetics and Developmental Biology (UMR3215 / U934)
The research Unit “Genetics and Developmental Biology” of Institut Curie is composed of nine teams addressing fundamental questions related to the development of organisms and its pathological dysfunctions.
Teams
Key figures
16
publications in 2020
3
ongoing ERC in 2020
24
PhD Students in 2020
Key publications
All publications
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Brain adiponectin signaling controls peripheral insulin response in DrosophilaNature Communications
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News
All news
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Shadocks et embryons, même combatDurant ses tous premiers jours, l’embryon de mammifère forme un lumen, une poche remplie d’eau dont la position détermine l’endroit par lequel l’embryon s’attache à l’utérus maternel. Dans une étude dirigée par le Dr Jean-Léon Maître, chef de l’équipe Mécanique du développement des mammifères (CNRS UMR3215 / Inserm U934 / Sorbonne Université) et publiée dans la revue Nature Cell Biology, il est expliqué comment des milliers de pompes, les blebs inversés, contribuent à la formation de ce lumen.13/09/2024 -
Drs. Allison Bardin and Valérie Borde elected members of the European EMBO organizationTo mark its 60th anniversary, the European Molecular Biology Organization (EMBO) has unveiled its 100 new members. Among them are nine French researchers, including Drs. Allison Bardin and Valérie Borde, team leaders at Institut Curie Research Center. Their mission: to promote the life sciences, guide strategic research choices and encourage the emergence of a new generation of excellent researchers.09/07/2024 -
Dr. Phong Nguyen a new junior team leader in Paris, explores cardiac regenerationDr. Phong Nguyen recently arrived at Institut Curie Research Center and just created a new team in the Genetics and Developmental Biology Unit (CNRS UMR3215 / Inserm U934 / Sorbonne University) in Paris. This team focuses on the processes that enable the heart to heal following an injury, based on the cardiac regeneration model observed in zebrafish.20/06/2024 -
Cell contraction drive the initial shaping of human embryosHuman embryo compaction, an essential step in the first days of an embryo’s development, is driven by the contractility of its cells. This is the finding of a team of scientists from CNRS, Institut Curie, Inserm, AP-HP and the Collège de France.02/05/2024 -
Congratulations to Dr. Jean-Léon Maître, recipient of the Richard Lounsbery AwardDr. Jean-Léon Maître, head of the Mechanics of Mammalian Development team, has been honored with the prestigious Richard Lounsbery Award by the French Academy of Sciences and the American National Academy of Sciences (NAS). The award recognizes the research carried out by his team to understand the mechanisms underlying the construction of the mammalian embryo.15/03/2024 -
Embryo fragmentation under the microscopeDuring the early days of its existence, cells of human embryos may fragment. This phenomenon is common and affects the embryo’s survival. In a study published in EMBO Journal, researchers from CNRS and Institut Curie used a “light-sheet” microscope to discover that cell fragmentation is caused, in mouse models, by contractions on the surface of the embryo and occur when signals persist abnormally from when the maternal oocyte is formed.22/08/2023
Scientific events
All scientific events
17 Oct
2024
Institutional seminar
10h-23h
What does the Epigenome do? From molecular function to developmental phenotype
Research Bio Overview:
Jamie Hackett is a group leader at the European Molecular Biology Laboratory (EMBL), within the Epigenetics and Neurobiology unit in Rome, Italy. He obtained his PhD at the University of Edinburgh, and completed postdoctoral training at the University of Cambridge, UK, under Prof. Azim Surani. The Hackett group investigates the fundamental principles of epigenetic regulat
Jamie Hackett is a group leader at the European Molecular Biology Laboratory (EMBL), within the Epigenetics and Neurobiology unit in Rome, Italy. He obtained his PhD at the University of Edinburgh, and completed postdoctoral training at the University of Cambridge, UK, under Prof. Azim Surani. The Hackett group investigates the fundamental principles of epigenetic regulat
10 Oct
2024
Institutional seminar
10h-23h
Decoding transcriptional regulation
In higher eukaryotes, genes are expressed dynamically in complex spatial and temporal patterns, which are progressively refined to set up body plans and define specific cell-types. The information about when and where each gene is to be expressed is encoded in the sequences of promoter-, enhancer- and silencer regions and realized by transcription factor and cofactor proteins.
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30 Sep
2024
Seminar
14h-23h
Stem Cell Microenvironments in Planarians Are Regulated by Multiple Cell Types Across Three Germ Layers
The functions of stem cells during tissue regeneration are partly regulated by extrinsic signals from the surrounding microenvironment composed of an extracellular matrix (ECM), making it critical to understand these signals for the advancement of regenerative medicine. Recently, many studies using vertebrates have demonstrated that stem cell microenvironments are maintained by different cell type
20 Sep
2024
Seminar
10h-23h
New Insights into the Vertebrate Head through Lineage Tracing and Single Cell Approaches
Despite apparent differences between humans and fish, our biological similarities are more profound than commonly recognized. This presentation explores how zebrafish research yields valuable insights into developmental processes, tissue functions, and models for human congenital disorders. Our research group employs a combination of lineage tracing and single-cell analysis techniques, leading to
19 Sep
2024
Institutional seminar
10h-23h
Tracing the protection mechanisms against mammary tumour initiation.
Oncogenic mutations are abundant in tissues of healthy individuals, but rarely form tumours. Yet, the underlying protection mechanisms are largely unknown. To resolve these mechanisms in murine mammary tissue, we use lineage tracing to map the fate of wild-type and Brca1−/−;Trp53−/− cells, and find that both follow a similar pattern of loss and spread within ducts. Clonal a