Membrane Mechanics and Dynamics of Intracellular Signaling

Team

CHRISTOPHE LAMAZE

Membrane Mechanics and Dynamics of Intracellular Signaling

Projects developed in the “Membrane Dynamics and Mechanics of Intracellular Signaling” team are based on the new concepts and original assays developed by the team for the last ten years to investigate the Cell Biology of membrane trafficking and mechanics and its role in intracellular signaling.

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Members

CHRISTOPHE LAMAZE

Deputy Director of Research Unit

CEDRIC BLOUIN

Permanent Researcher

CHAFIAA BOUGUECHTOULI

Engineer

PAMELA GONZALEZ TRONCOSO

Engineer

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CELINE GRACIA

Engineer

ANA JOAQUINA JIMENEZ SALAZAR

Post-Doctoral Researcher

CRISTIAN IGNACIO SAQUEL ESCOBEDO

Post-Doctoral Researcher

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VIBHA SINGH

Post-Doctoral Researcher

ZHI-QIAN WU

PhD Student

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CHRISTINE VIARIS DE LESEGNO

Chargé de mission d'enseignement

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Key publications

2023

STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation
Nature Cell Biology

Natacha Zanin, Christine Viaris de Lesegno, Joanna Podkalicka, Thomas Meyer, Pamela Gonzalez Troncoso, Philippe Bun, Lydia Danglot, Daniela Chmiest, Sylvie Urbé, Jacob Piehler, Cédric M. Blouin, Christophe Lamaze
(2023 01 Mar)
2022

Small Molecule Inhibitors of Interferon‐Induced JAK‐STAT Signalling
Angewandte Chemie International Edition

Leishemba K. Thoidingjam, Cédric M. Blouin, Christine Gaillet, Aurélien Brion, Stéphanie Solier, Supaporn Niyomchon, Ahmed El Marjou, Sara Mouasni, Fernando E. Sepulveda, Geneviève de Saint Basile, Christophe Lamaze, Raphaël Rodriguez
(2022 08 Aug)
2021

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes
Communications Biology

Alena Ivashenka, Christian Wunder, Valerie Chambon, Roger Sandhoff, Richard Jennemann, Estelle Dransart, Katrina Podsypanina, Bérangère Lombard, Damarys Loew, Christophe Lamaze, Francoise Poirier, Hermann-Josef Gröne, Ludger Johannes, Massiullah Shafaq-Zadah
(2021 01 Dec)
2020

Coupling of melanocyte signaling and mechanics by caveolae is required for human skin pigmentation
Nature Communications

Lia Domingues, Ilse Hurbain, Floriane Gilles-Marsens, Julia Sirés-Campos, Nathalie André, Melissa Dewulf, Maryse Romao, Christine Viaris de Lesegno, Anne-Sophie Macé, Cédric Blouin, Christelle Guéré, Katell Vié, Graça Raposo, Christophe Lamaze, Cédric Delevoye
(2020 01 Dec)
2019

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
Nature Communications

Melissa Dewulf, Darius Vasco Köster, Bidisha Sinha, Christine Viaris de Lesegno, Valérie Chambon, Anne Bigot, Mona Bensalah, Elisa Negroni, Nicolas Tardif, Joanna Podkalicka, Ludger Johannes, Pierre Nassoy, Gillian Butler-Browne, Christophe Lamaze, Cedric M. Blouin
(2019 01 Dec)
2018

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription
Journal of Cell Biology

Stéphanie Torrino, Wei-Wei Shen, Cédric M. Blouin, Satish Kailasam Mani, Christine Viaris de Lesegno, Pierre Bost, Alexandre Grassart, Darius Köster, Cesar Augusto Valades-Cruz, Valérie Chambon, Ludger Johannes, Paolo Pierobon, Vassili Soumelis, Catherine Coirault, Stéphane Vassilopoulos, Christophe Lamaze
(2018 03 Dec)
2016

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex
Nature Communications

Daniela Chmiest, Nanaocha Sharma, Natacha Zanin, Christine Viaris de Lesegno, Massiullah Shafaq-Zadah, Vonick Sibut, Florent Dingli, Philippe Hupé, Stephan Wilmes, Jacob Piehler, Damarys Loew, Ludger Johannes, Gideon Schreiber, Christophe Lamaze
(2016 01 Dec)
2016

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation
Cell

Cédric M. Blouin, Yannick Hamon, Pauline Gonnord, Cédric Boularan, Jérémy Kagan, Christine Viaris de Lesegno, Richard Ruez, Sébastien Mailfert, Nicolas Bertaux, Damarys Loew, Christian Wunder, Ludger Johannes, Guillaume Vogt, Francesc-Xabier Contreras, Didier Marguet, Jean-Laurent Casanova, Céline Galès, Hai-Tao He, Christophe Lamaze
(2016 01 Aug)

All publications

News

The secret of an essential cell signaling pathway has finally been revealed

A membrane receptor is like a lock, a ligand is like a key and when one binds to the other, cell activity is triggered. Although this relatively simple pattern often works, a team at Institut Curie has just revealed in Nature Cell Biology that it is not always as simple as that: for the JAK-STAT signaling pathway, vital in several pathologies, it all happens in the endosome.

01/03/2023

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