Innate immunity
Innate immunity is an ancient and universal form of defence against damages, threats and pathogens such as viruses. How the innate immunity distinguishes self from non-self (e.g. viruses) inside cells remains poorly understood. As a result, the ability to exploit innate immunity for anti-viral treatments, vaccines or cancer immunotherapy has remained limited.
The lab investigates the regulation, function and application of innate immunity. Our goal is to discover the molecular mechanisms that enable the immune system to distinguish self from non-self inside cells. We study HIV, other viruses and auto-immunity and development of the immune system. We use primary human immune cells, mouse models, cell lines and computational tools. We develop applications of our research for clinical use.
For more information, click on the following link Nicolas Manel Lab.
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Bloom syndrome protein restrains innate immune sensing of micronuclei by cGASJournal of Experimental Medicine
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Constitutive resistance to viral infection in human CD141 + dendritic cellsScience Immunology
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Immunotherapy: a new two-in-one weapon against resistant tumorsPress on the gas pedal and lift the break; this is the innovative idea of Dr. Nicolas Manel, Inserm researcher and team leader at Institut Curie (Immunity and Cancer unit - Institut Curie, Inserm) to improve the response to immunotherapy.20/01/2023 -
Yolanda Prezado, Carsten Janke, Céline Vallot et Nicolas Manel récompensés par l’Académie des sciencesLe 23 novembre, l’Académie des sciences a remis, lors d'une cérémonie exceptionnelle sous la coupole de l’Institut de France, l’ensemble des prix et médailles qu’elle a attribués en 2021. Quatre chercheurs et médecins de l’Institut Curie ont été distingués. Toutes nos félicitations !25/11/2021 -
Cancer du sein : la rupture du noyau des cellules tumorales favorise leur disséminationQuand les cellules se multiplient et migrent, elles peuvent être comprimées et leur noyau se briser. Ce phénomène entraine des détériorations de leur ADN et des scientifiques du CNRS, de l’Institut Curie et de l’Inserm viennent de montrer qu’il facilite ainsi la dissémination des cellules cancéreuses des tumeurs mammaires.22/09/2021