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Innate immunity

Innate immunity is an ancient and universal form of defence against damages, threats and pathogens such as viruses. How the innate immunity distinguishes self from non-self (e.g. viruses) inside cells remains poorly understood. As a result, the ability to exploit innate immunity for anti-viral treatments, vaccines or cancer immunotherapy has remained limited.

The lab investigates the regulation, function and application of innate immunity. Our goal is to discover the molecular mechanisms that enable the immune system to distinguish self from non-self inside cells. We study HIV, other viruses and auto-immunity and development of the immune system. We use primary human immune cells, mouse models, cell lines and computational tools. We develop applications of our research for clinical use.

For more information, click on the following link Nicolas Manel Lab.

Key publications
  • Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
    Guilherme Pedreira de Freitas Nader, Sonia Agüera-Gonzalez, Fiona Routet, Matthieu Gratia, Mathieu Maurin, Valeria Cancila, Clotilde Cadart, Andrea Palamidessi, Rodrigo Nalio Ramos, Mabel San Roman, Matteo Gentili, Ayako Yamada, Alice Williart, Catalina Lodillinsky, Emilie Lagoutte, Catherine Villard, Jean-Louis Viovy, Claudio Tripodo, Jérôme Galon, Giorgio Scita, Nicolas Manel, Philippe Chavrier, Matthieu Piel
  • Constitutive resistance to viral infection in human CD141 + dendritic cells
    Science Immunology
    Aymeric Silvin, Chun I Yu, Xavier Lahaye, Francesco Imperatore, Jean-Baptiste Brault, Sylvain Cardinaud, Christian Becker, Wing-Hong Kwan, Cécile Conrad, Mathieu Maurin, Christel Goudot, Santy Marques-Ladeira, Yuanyuan Wang, Virginia Pascual, Esperanza Anguiano, Randy A. Albrecht, Matteo Iannacone, Adolfo García-Sastre, Bruno Goud, Marc Dalod, Arnaud Moris, Miriam Merad, A. Karolina Palucka, Nicolas Manel
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