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Systems Biology of cell Polarity and Cell Division (Bio6)

Our team studies different processes happening in the cell: cell migration, cell volume/mass regulation, cell division. We are interested by processes involving the cytoskeleton, organelles and their relation with mechanosensitivity. We develop and use innovative tools based on nano and micro-fabrication techniques, to control and modulate the main physical and chemical parameters of the cell micro-environment.

These tools are coupled with high quality quantitative microscopy, and used alongside molecular and cell biology techniques, to obtain a quantitative description of the cell behavior. As well as highlighting new basic concepts about cell behavior, our multidisciplinary approach leads to the development of novel tools with potential applications in biomedical research.

The focus of our current research is how cells proliferate and migrate when space is limited. We want to understand how cells (immune cells and cancer cells) can produce efficient motion under confinement and squeeze through small holes, and how physical constrains affect dividing cells.

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