Our team studies different processes happening in the cell: cell migration, cell volume/mass regulation, cell division. We are interested by processes involving the cytoskeleton, organelles and their relation with mechanosensitivity. We develop and use innovative tools based on nano and micro-fabrication techniques, to control and modulate the main physical and chemical parameters of the cell micro-environment.
These tools are coupled with high quality quantitative microscopy, and used alongside molecular and cell biology techniques, to obtain a quantitative description of the cell behavior. As well as highlighting new basic concepts about cell behavior, our multidisciplinary approach leads to the development of novel tools with potential applications in biomedical research.
The focus of our current research is how cells proliferate and migrate when space is limited. We want to understand how cells (immune cells and cancer cells) can produce efficient motion under confinement and squeeze through small holes, and how physical constrains affect dividing cells.
Dr. Matthieu Piel, winner of the Fondation Allianz - Institut de France prizeDr. Matthieu Piel, head of the Systems Biology of Cell Polarity and Cell Division (BIO6) team (CNRS UMR144/Sorbonne Université) has been honored by the French Academy of Sciences for his research into the influence of physical constraints on immune and cancer cells. He was awarded the Fondation Allianz - Institut de France prize.04/12/2023
Congratulations to Matthieu Piel, CNRS Silver Medal 2023Matthieu Piel, head of the Systems Biology of Cell Polarity and Cell Division team at Institut Curie’s Research Center, is the lucky winner of the CNRS Silver Medal 2023. This award recognizes the originality, quality and importance of his work, both nationally and internationally.28/03/2023
Three research projects at Institut Curie financed by the ERC Synergy GrantThree projects at Institut Curie are laureate of the highly selective and prestigious Synergy Grant 2022 program, awarded by the European Research Council. These three grants, for an amount of 10 million euros each, shine a light on Institut Curie’s excellence and its teams in cellular biology. A breakthrough field to further the fight against cancer.28/10/2022
Cancer du sein : la rupture du noyau des cellules tumorales favorise leur disséminationQuand les cellules se multiplient et migrent, elles peuvent être comprimées et leur noyau se briser. Ce phénomène entraine des détériorations de leur ADN et des scientifiques du CNRS, de l’Institut Curie et de l’Inserm viennent de montrer qu’il facilite ainsi la dissémination des cellules cancéreuses des tumeurs mammaires.22/09/2021