Team
Chemical Biology of Cancer
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Team
RAPHAEL RODRIGUEZ
Chemical Biology of Cancer
Nature is dominated by chemically favoured processes. While biology is prone to evolution, universal principles of physical chemistry are not (at least not on the same time scale). It is my opinion that life has evolved mechanisms to circumvent undesired chemistry’’ -Raphaël Rodriguez-
Members
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Patents
Key publications
All publications
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CD44 regulates epigenetic plasticity by mediating iron endocytosisNature Chemistry
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Visualizing biologically active small molecules in cells using click chemistryNature Reviews Chemistry
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Chromatin Regulates Genome Targeting with CisplatinAngewandte Chemie International Edition
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Click Quantitative Mass Spectrometry Identifies PIWIL3 as a Mechanistic Target of RNA Interference Activator Enoxacin in Cancer CellsJournal of the American Chemical Society
News
All news
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Exploiting iron chemistry to beat cancer
The work carried out at Institut Curie by Raphaël Rodriguez’ “Chemical Biology of Cancer” team revealed a new gateway to induce the death of cells with metastatic potential in connection with iron metabolism. Together with Marcus Conrad (Germany), the ferroptosis pioneer, and Stuart Schreiber (United States), father of modern chemical biology, they conceptualize new therapeutic approaches in an article that has just been published in the journal Molecular Cell.04/01/2022 -
Une nouvelle molécule pour traiter des leucémies résistantes aux traitements conventionnels
Une nouvelle molécule, l’ironomycine, développée par Raphaël Rodriguez à l’Institut Curie, permet d’induire la mort des cellules cancéreuses dans les leucémies myéloïdes aigües grâce à un mécanisme de mort cellulaire inédit.06/12/2021
