Nano-therapies
Claire Wilhelm
claire.wilhelm@curie.fr
Here we are using our knowledge of materials science to advance the field of nanomedicine, by adopting the materials angle from the outset. Our goals have been to provide the fullest possible picture of the modes of action and fates of nanoparticles in their biological target environments. In particular, we proposed combined and synergistic cancer solutions by applying multiple stimuli to the same nanomaterials, pioneered the use of magnetic nanoparticles as photothermal tools, and discovered a thermo-ferroptotic combined therapy. We have also devoted many efforts to explore whether and how nanoparticles properties can be affected once achieving their therapeutic mission, as they journey within their cellular targets or through the body, a central issue for all nanomedicine applications of nanoparticles. For instance, we demonstrated that a massive biodegradation of magnetic nanoparticles can happen, with degradation products being integrated by iron metabolism pathways, or serving for intracellular recrystallization of nanoparticles anew.
SELECTION OF RECENT RELATED PUBLICATIONS
Janus magnetic-plasmonic nanoparticles for magnetically guided and thermally activated cancer therapy. Espinosa A, Reguera J, Curcio A, Muñoz A, Van de Walle A, Liz-Marzán L, Wilhelm C. Small 16 1904960 (2020)
Endosomal confinement of gold nanospheres, nanorods and nanoraspberries governs their photothermal identity and is beneficial for cancer cells therapy. Plan Sangnier A, Van de Walle A, Motte L, Guenin E, Lalatonne Y, Wilhelm C. Advanced Biosystems 4, 1900284 (2020)
Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows. Plan Sangnier A, Aufaure R, Cheong S, Motte L, Palpant B, Tilley RD, Guenin E, Wilhelm C*, Lalatonne Y*. Chemical Communications, 55, 4055-4058 (2019)
Iron Oxide Nanoflowers @ CuS Hybrids for Cancer Tri-Therapy: Interplay of Photothermal Therapy, Magnetic Hyperthermia and Photodynamic Therapy. Curcio A, Silva AKA, Cabano S, Espinosa A, Baptiste B, Menguy N, Wilhelm C*, Abou-Hassan A*. Theranostics, 9, 1288-1302 (2019)
Magnetic (hyper)thermia or photo-thermia? Progressive comparison of iron oxide and gold nanoparticles heating in water, in cells, and in vivo. Espinosa A, Kolosnjaj-Tabi J, Abou-Hassan A, Plan Sangnier A, Curcio A, Silva AKA, Di Corato R, Neveu S, Pellegrino T, Liz-Marzán LM, Wilhelm C. Advanced Functional Materials 1803660 (2018)
Intracellular Biodegradation of Ag Nanoparticles, Storage in Ferritin, and Protection by Au Shell for Enhanced Photothermal Therapy. Espinosa A, Curcio A, Cabana S, Radtke G, Bugnet M, Kolosnjaj-Tabi J, Péchoux C, Alvarez-Lorenzo C, Botton GA, Silva AKA, Abou-Hassan A, Wilhelm C. ACS nano 12, 6523–6535 (2018)
Targeted thermal therapy with genetically engineered magnetite magnetosomes@RGD: Photothermia is far more efficient than magnetic hyperthermia. Plan A, Preveral S, Curcio A, Silva A, Lefèvre CT, Pignol D, Lalatonne Y, Wilhelm C. Journal of Controlled Release 279, 271-281 (2018)
Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment Espinosa A, Di Corato R, Kolosnjaj-Tabi J, Flaud P, Pellegrino T, Wilhelm C. ACS Nano, 10, 2436-46 (2016)
Cancer cell internalisation of gold nanostars impacts their photothermal efficiency in vitro and in vivo: towards a plasmonic thermal fingerprint in tumoral environment Espinosa A, Silva AKA, Sánchez-Iglesias A, Grzelczak M, Péchoux C, Desboeufs K, Liz-Marzán LM, Wilhelm C. Advanced HealthCare Materials, 5, 1040- 48 (2016)
Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes. Di Corato R, Béalle G, Kolosnjaj-Tabi J, Espinosa A, Clément O, Silva AKA, Ménager C, Wilhelm C. ACS Nano, 9, 2904-2916 (2015) http://www2.cnrs.fr/presse/communique/3969.htm