Mechanics of Mammalian Development
We want to understand how the mammalian embryo shapes itself. For this, we study how the forces that deform the embryo are generated. Usual suspects are the cytoskeleton, adhesion molecules and intercellular fluid. We use microscopy to observe the deformations, biophysical tools to measure the forces, and genetics to perturb them.
99SEC to understand developmental biology (video in french)
Podcast France Inter In Utero Les sept premiers jours et La danse des cellules (in french)
Award from the Fondation Bettencourt Schueller (video in french)
Seminar at Cité des sciences et de l'industrie (video in french)
Award from the CNRS (video in french)
ERC Starting Grant (video in english)
Talk at College de France (video in english)
Talk at College de France (video in english)
Talk Multiscale integration in biological systems (video in english)
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Pulsatile cell-autonomous contractility drives compaction in the mouse embryoNature Cell Biology
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Embryo fragmentation under the microscopeDuring the early days of its existence, cells of human embryos may fragment. This phenomenon is common and affects the embryo’s survival. In a study published in EMBO Journal, researchers from CNRS and Institut Curie used a “light-sheet” microscope to discover that cell fragmentation is caused, in mouse models, by contractions on the surface of the embryo and occur when signals persist abnormally from when the maternal oocyte is formed.22/08/2023 -
Institut Curie awarded yet another prestigious ERC grantThis Tuesday 31 January, Institut Curie Research Center biology researcher Jean-Léon Maître was awarded one of the European Research Council’s coveted grants. With two million Euros awarded over five years, the grant will allow the scientist to deepen our understanding of the physical forces at play in how the human body is structured.31/01/2023
