Team
Extracellular vesicles, immune responses and cancer
Thematic areas of research:
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Team
CLOTILDE THERY
Extracellular vesicles, immune responses and cancer
Cells release in their environment membrane-enclosed vesicles collectively called “Extracellular Vesicles” (EVs), which are thought to act as intercellular messengers. Exosomes are a type of EV formed inside endocytic compartments, the multivesicular bodies (MVBs) and secreted upon fusion of these MVBs with the plasma membrane. Other EVs, called microvesicles or ectosomes, are released by direct budding from the plasma membrane. The team is studying these different EVs, their biogenesis and release molecular mechanisms, and their functions, in the context of communication between tumors and the immune system.
Members
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Past members
GREGORY LAVIEU
Research Officer
MERCEDES TKACH
Post-Doctoral Researcher
ELEONORA GRISARD
Post-Doctoral Researcher
MATHILDE MATHIEU
PhD Student
EMELINE BONSERGENT
PhD Student
JESSIE THALMENSI
Engineer
Key publications
All publications
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Extracellular vesicles containing ACE2 efficiently prevent infection by SARS‐CoV‐2 Spike protein‐containing virusJournal of Extracellular Vesicles
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Acetylcholinesterase is not a generic marker of extracellular vesiclesJournal of Extracellular Vesicles
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Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypesProceedings of the National Academy of Sciences
News
All news
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Cryomicroscopy: the Research Center thinks bigThe brand new Glacios Cryo-TEM™ by Thermo Fischer was received in February at Institut Curie’s Research Center, This powerful cryo-electron microscope worth over 2 million euros will enable researchers to observe proteins at unprecedented resolution. A new opportunity to understand their function and the alterations responsible for diseases, particularly cancer.17/04/2023 -
L’Institut Curie, catalyseur d’innovation avec 101 inventeurs à son actifEn cette journée mondiale de l’inventeur, l’Institut Curie salue ses 101 salariés inventeurs comptabilisés en 2022. Un chiffre impressionnant qui traduit l’engagement de l’Institut Curie à encourager l’innovation auprès de ses collaborateurs, ainsi que l’excellence et l’inventivité des travaux des chercheurs, médecins et soignants, au bénéfice des patients.08/11/2022 -
Identification of a substance that acts on the release of extracellular vesicles and may have pro-tumor effectsAfter conducting a high-throughput screening of a drug library, an Institut Curie team has identified a substance, homosalate, that boosts the secretion of extracellular vesicles in breast cancer cells and could promote the development of tumors.20/07/2022 -
Prostate cancer: non-coding RNAs in the urinary extracellular vesicles are now in playA pioneering study deciphers the complexity of non-coding RNAs in the urinary extracellular vesicles, which play a role in prostate cancer.05/07/2022 -
Extracellular vesicles to fight triple-negative breast cancerTriple-negative breast cancer is a tumor for which the search for new therapeutic solutions is crucial. Clotilde Théry’s team at Institut Curie has just shown for the first time, and unexpectedly, that extracellular vesicles in tumors induce macrophages that could promote anti-tumor responses.04/05/2022 -
Distinguishing between vesicles to better understand tumor progressionCancer cells secrete small “cell bubbles” which are thought to be important for tumor progression. At Institut Curie, Clotilde Théry’s “Extracellular vesicles, immune response and cancer” team (Inserm U392), made a major advance in characterizing them. Published in Nature Communications, this result could end the confusion which has been impeding this field of research.09/08/2021
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