Bioinformatics Engineer in Cell Therapy (M/F)

Date de clôture

09/02/2024

Secteur

Centre de Recherche

The “Institut Curie” is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. The position will be located in CellAction, the new Cellular Therapy Center of the Institut Curie at Suresnes, in border of Paris.

Laboratory

The position is open as a collaboration between the team of Cecile Alanio (Clinical Immunology and Immunomonitoring lab), CellAction (Cell Therapy Platform led by Dr Marion Alcantara and Dr Sebastian Amigorena), and the lab of Joshua Waterfall (Integrative Functional Cancer Genomics). The successful candidate will work in a strong bioinformatics environment in close collaboration with wet-lab biologists and clinicians.

Missions

CAR T cell therapies are tremendously effective in hematological malignancies. Yet, their application to solid tumors is complicated, due to inherent obstacles that need to be overcome. Our work is to launch preclinical and postclinical work on CAR T cells to improve cellular therapies for the treatment of patients with solid tumors.

We seek a computational scientist interested in cellular therapy to join a multi-disciplinary team of clinicians and immunologists applying cutting-edge single cell multi-omics approaches to characterize cell therapies and immune interactions. This includes molecular characterization (RNAseq, chromatin profiling) of clinically annotated patient tumor samples and mice tumors, as well as scRNA/TCRseq of the immune microenvironment before and after cellular therapies.

Description of the activities

- Analysis of transcriptomic datasets generated in house (scRNA-Seq, bulk RNASeq)

- Analysis of single cell epigenomics datasets (scATAC-Seq, CHIP-Seq)

- Database exploration (GTEx, TCGA)

- Graphical representation of the scientific results

Training and experience required

- We expect a candidate with a PhD in computational genomics or an M2 with equivalent research experience.

- Experience in management and analysis of genome-scale data (RNAseq, scRNAseq)

- Experience in use of bioinformatics and bio-statistics tools (R, python)

- Experience with pipeline management tools (Nextflow, snakemake, kedro)

- Strong background in computational genomics applied to either oncology or immunology, preferably both

Skills required

- Skill to work on large computing clusters

- Skill to work independently and in collaboration with biologists

- Presentation and communication of results

- Good knowledge of English both spoken and written

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract

Starting date: Sept 1st, 2024

Duration: 18 months

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Suresnes (CellAction, DocCity) until 205. Saint Cloud from 2025 on - Public tranportation

Reference: NA

Contact

Please send your CV, letter of motivation and 2 references

Publication date: 07th of May 2024

Deadline for application: NA

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf