IE-IR Research Engineer (M/F)

Laboratory

The research group DNA repair mechanisms in cancers (Ceccaldi Lab, https://institut-curie.org/team/ceccaldi) is seeking an engineer (IE or IR) driving cutting-edge research projects aiming at understanding the mechanisms regulating genome stability.

In the recent years, our team significant contributions to the field of genome stability and tumor biology. Focusing on compensatory mechanisms employed by cancer cells with defects in homologous recombination (HR)-mediated repair, we shed light on new mechanisms and pathways controlling genome stability and Homologous Recombination (HR)-deficient tumor survival.

From a translational point of view, our group has identified (and developed inhibitors against) new drug targets for the treatment of breast and ovarian tumors target and highlighted the importance of studying the relationships between the different DNA repair pathways to better understand their interaction and exploit them for therapeutic purposes. Our long-term research goals hinge on the critical need for 1) new scientific approaches to discover additional regulators and effectors of genome stability, 2) basic understanding of interconnections between DNA repair processes, and 3) new drug development and biomarkers for anticancer targeted therapy.

Recent publication from the team

1.             Zhou, J. et al. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nature Cancer, 2021.

2.             Gelot, C. et al. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Nature, 2023.

9.             Kovacs, M. T. et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Molecular Cell, 2023.

8.             Musiani, D. et al. SMUG1 trapping at unprocessed uracil upon UNG inhibition triggers homologous recombination and selectively kills BRCA1/2-deficient tumors. In revision, 2024.

Missions

The applicant will work on a project aiming at deciphering the molecular mechanism(s) of mitotic repair. The applicant will work closely with a PhD student and a postdoctoral fellow and conduct experiments including:

-          Cloning

-          Protein purification (E. Coli, Insect cells)

-          Protein-protein interaction assay

-          Microscopy

Prospective applicants should have a master or Ph.D degree in molecular biology or biochemistry. The ideal applicant has further expertise in biochemistry or super-resolution microscopy. Great communication skills are needed, together with appropriate organizational capacity.

Professional English and/or French level required.

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract

Starting date:  As soon as possible

Duration: 3 years

Working time: full time - number of days – 39 hours per week

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Contact

Please send your application including your CV, a letter of motivation explaining why you would like to join our team and contact information of at least two referees.

Publication date: 07th of May 2024

Deadline for application:  31st of July 2024

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf