Postdoctoral Position in Genomics (bio informatics) (M/F)

Laboratory

We are looking for motivated and productive post-doctoral fellows to join our team “NON-CODING RNA, EPIGENETICS, AND GENOMES FLUIDITY” headed by Antonin MORILLON (https://curie.fr/equipe/morillon), at Institut Curie, Paris, France. Our research interests focus on regulatory noncoding (nc)RNAs. In high eukaryotes, regulatory ncRNAs have been shown to regulate gene expression, chromatin domains and genome stability. There is a growing amount of evidence suggesting that they play a central role in cellular homeostasis during normal and pathological development. Regulatory ncRNA can be classified in small noncoding RNAs that take part of RNAi pathways; and long noncoding RNAs of at least 200 nucleotides in length. The latter transcripts present the most prevalent class of noncoding genes in the human genome and show a high diversity in structure and functions.

We develop original high throughput sequencing and computational approaches allowing exhaustive transcriptomic studies in yeast and humans and identification of novel lncRNA species. They are further studied for their fate and function in both eukaryotic systems. Finally, we investigate clinical relevance of lncRNAs as non-invasive prognostic biomarkers in cancer.

The project

Triple Negative Breast Cancers (TNBC) have the worst prognosis among breast cancers and lack coding molecular target. Long noncoding RNAs (lncRNAs) and circRNAs were shown to be involved in different steps of cancer biology. Our aim is to identify a complete dataset of circulating cell-free (in extracellular vesicles) lncRNAs, circRNAs, and novel genes playing a role in TNBC chemoresistance, and immune response escape, and to focus on phenotype and function associated with deregulation of most prominent lncRNAs. Our research is funded by an INCA grant in collaboration with Clotilde Théry lab (Curie).

Bibliographical references

1.     Andjus et al. RNA 2024, 3

2.     Bhargava et al. iScience 2023, 26, 12, 108449

3.     Foretek, et al. Research Square 2023

4.     Yague-Sanz et al. Nat Commun 2023, 14, 3587

5.     Almeida et al. JEv 2022, 11 (5), e12210

6.     Jarroux, et al. EMBO Rep 2021, 22: e50193

7.     Morillon A & Gautheret D. Genome Biol 2019, 20, 1–7.

Constraints and risks  

-          Use of biological/chemical products

Training and Skills required:

We are looking for a postdoc in bioinformatics candidate:

-          Candidate should hold a PhD in biology, cellular biology, or related areas.

-          Fresh PhD graduate or with up to 3 years of postdoctoral experience. Applicants are invited to indicate the specific level of experience is these subjects.

o    Expertise in the analysis of transcriptomics datasets.

o    Proficient in at least one programming language for data analysis (R, python,…)

o    Proficient in Linux and supercomputer infrastructure (slurm or other)

o    Optional: experience with (NextFlow, SnakeMake…), and containerization (Docker, Singularity,…)

-          Language skills: Fluency in English level and communication skills. French is a plus.

Abilities

-          Ability to work independently, managerial abilities, aptitude for working in a team.

-          The candidate should be highly motivated, curious, and enthusiastic to work in a collaborative team.

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract (COD)

Starting date:  As soon as possible

Duration: 18 months (renewable contract up to 3 years)

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris, 5eme

Reference: NA

 Please send your CV, letter of motivation and 3 references

CVs to be processed on the go, therefore the position could be filled before the deadline for applications.

Publication date: 19/06/2024

Deadline for application: 30/09/2024

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf