Genome functions in Space and Time

Our team investigates how the functional, dynamical, structural, and mechanical properties of mammalian chromosomes are interconnected, using an interdisciplinary approach at the interface between physics and biology. We aim to address fundamental questions through the development of original methodologies.

We combine advanced microscopy, micro-manipulation technologies, and polymer modeling to explore:

• the physical principles underlying the 3D organization, dynamics, and mechanics of interphase chromosomes
• the functional implications of this organization for transcriptional regulation.