Unit
Nuclear dynamics (UMR3664)
Thematic areas of research:
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Unit
ANGELA TADDEI / NATHALIE DOSTATNI
Nuclear dynamics (UMR3664)
Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism.
Teams
Key figures
18
nationalities for 55 people
6
model systems
37200
billion nuclei in the human body
Key publications
All publications
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CENP-A overexpression promotes distinct fates in human cells, depending on p53 statusCommunications Biology
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3 minutes to precisely measure morphogen concentrationPLOS Genetics
News
All news
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A Key Protein for DNA Repair Observed in YeastFor the first time, researchers from Institute Curie, led by Dr. Angela Taddei, have highlighted one of the cellular mechanisms that come into play during DNA repair.21/08/2023 -
Institut Curie - Institut Pasteur partnership: two joint projects to promote innovation and advancement of knowledgeImplementing their collaborative research strategy, Institut Curie and Institut Pasteur have raised the impressive amount of €600,000 to finance two research projects involving two teams from each organization. The MUCTOLIN project, looking at the role of tolerance induced by mucus during Listeria infection, and the TicTac project, which aims to study the effects of geometry on the healthy or cancerous status of a cell or on its development, were chosen.28/04/2023 -
Congratulations to Leïla Périé and Antoine Coulon, winners of the CNRS Bronze Medal 2023Two scientists from the Research Center have just been honored by the CNRS. Each year the organization rewards the women and men who have made the greatest contributions to its reputation and progress in research. The 2023 edition once again recognizes the excellence of the researchers working at Institut Curie’s Research Center.04/04/2023 -
Manipulating chromosomes in living cells reveals that they are fluidFor the first time, scientists from CNRS, Institut Curie and Sorbonne Université have been able to act physically on chromosomes in living cells. By subjecting the chromosomes to different forces using magnets, they discovered that chromosomes are in fact very fluid – almost liquid – outside cell division phases. This study is published in Science on July 29, 2022.01/08/2022
Scientific events
All scientific events
19 Jun
2023
Seminar Nuclear dynamic series
14h-15h
Atypical genome folding and gene regulation by SMC complexes in the nematode C. elegans
In the majority of species studied thus far, chromosomes are organized into topologically associated domains (TADs). TAD formation depends on between cohesin, a member of the structural maintenance of chromosome (SMC) complexes family, and boundary sequence elements recognized by transcription factors. TADs are highly conserved across different cell types or species in syntenic regions and are cru
14 Jun
2023
Seminar Nuclear dynamic series
09h-10h
In time we trust: how precise temporal regulation of the genome is important for embryogenesis
How a single embryonic cell interprets its genome to give rise to the many diverse cell types that build an animal is one of nature’s enduring mysteries. Unravelling it promises to not only yield new insights into disorders of development and cancer, but also reveal the organizing principles of life. The genes that drive development each typically have many different enhancers. Properly coor
30 May
2023
Seminar
09h-10h
The various layers regulating genomic instability in cancer
Nuclear Dynamics Extras Seminar (UMR3664) & Medico-Scientific Program in Epigenetics (Joint Event)
Genomic instability is a major driving force of tumorigenesis. Our goal is to understand the mechanisms underlying genomic instability during cancer development, with a focus on the role of oncogene and tumor suppressor-affected networks, in DNA replication stress, transcription and chromatin
Genomic instability is a major driving force of tumorigenesis. Our goal is to understand the mechanisms underlying genomic instability during cancer development, with a focus on the role of oncogene and tumor suppressor-affected networks, in DNA replication stress, transcription and chromatin
17 May
2023
Seminar
16h-17h
The three-dimensional architecture of the human genome: understanding the physical mechanisms controlling gene expression
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. A theoretical model for chromatin (the minimal chromatin model) explains the folding of interphase chromosomes and generates chromosome
conformations consistent with experimental data is presented. The energy landscape of the model was derived by using the
conformations consistent with experimental data is presented. The energy landscape of the model was derived by using the
16 May
2023
Seminar
14h-15h
Epigenetic factor competition can reshape the EMT landscape in breast cancer cells
We are nearing the tenth anniversary of the first papers applying methods of computational systems biology to the study of the epithelial-mesenchymal transition (EMT) and its relevance to cancer metastasis. This undertaking has been a major success, leading to a much-improved understanding of EMT itself and its connection to tumor initiation and drug resistance. But of course, new questions have a