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Nuclear dynamics (UMR3664)

Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism.

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nationalities for 55 people
model systems
billion nuclei in the human body
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17 May
Seminar Nuclear dynamic series
Chromatin contortions to fit into the cricket sperm nucleus
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"Spermiogenesis is a radical case of differentiation whereby sperm cells acquire a compact and specialized morphology to accommodate the constraints of sexual reproduction while preserving their main cargo, an intact copy of the paternal genome. In animals, this often involves the replacement of most histones by sperm-specific nuclear basic protei
22 Apr
Seminar Nuclear dynamic series
Towards a quantitative understanding of long-range transcriptional regulation
In mammals, control of gene expression relies on tens of thousands of enhancer sequences that are differentially active in every cell type. Enhancers engage with target promoters often from large genomic distances and govern their spatio-temporal and quantitative expression dynamics. Despite their central role in gene regulation in health and disease, however, the principles by which enhancers sel
12 Apr
Seminar Nuclear dynamic series
Role of spatial chromatin (re)organization in recombinational DNA repair and genomic stability
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"Homologous recombination (HR) templates DNA double-strand break (DSB) repair off an intact homologous dsDNA “donor” molecule, which can exist in the form of a sister chromatid, a homologous chromosome, or dispersed repeats. HR fidelity partly depends on this competitive donor selection process, which embeds homology sampling by the RecA/Rad51
16 Mar
23 Mar
International Course Seminar
Epigenetics - 17th edition - From nuclear organization to metabolism and cell fate in normal state and diseases
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear function
8 Feb
Combining coevolution-driven predictions and experiments to elucidate the complexity of protein interaction networks
Predicting protein-protein interactions and characterizing their structural organization provides essential information to elucidate the molecular mechanisms underlying cross-talk between cellular pathways. Exploiting coevolution information has emerged over the last years as a major strategy for predicting the mode of recognition between proteins. Our recent methodological developments [1, 2] hav
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