To top
Nuclear dynamics (UMR3664)

Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism.

Key figures
nationalities for 55 people
model systems
billion nuclei in the human body
Key publications
All publications
All news
Scientific events
19 Jun
Seminar Nuclear dynamic series
Atypical genome folding and gene regulation by SMC complexes in the nematode C. elegans
In the majority of species studied thus far, chromosomes are organized into topologically associated domains (TADs). TAD formation depends on between cohesin, a member of the structural maintenance of chromosome (SMC) complexes family, and boundary sequence elements recognized by transcription factors. TADs are highly conserved across different cell types or species in syntenic regions and are cru
14 Jun
Seminar Nuclear dynamic series
In time we trust: how precise temporal regulation of the genome is important for embryogenesis
How a single embryonic cell interprets its genome to give rise to the many diverse cell types that build an animal is one of nature’s enduring mysteries. Unravelling it promises to not only yield new insights into disorders of development and cancer, but also reveal the organizing principles of life. The genes that drive development each typically have many different enhancers. Properly coor
17 May
The three-dimensional architecture of the human genome: understanding the physical mechanisms controlling gene expression
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. A theoretical model for chromatin (the minimal chromatin model) explains the folding of interphase chromosomes and generates chromosome

conformations consistent with experimental data is presented. The energy landscape of the model was derived by using the
16 May
Epigenetic factor competition can reshape the EMT landscape in breast cancer cells
We are nearing the tenth anniversary of the first papers applying methods of computational systems biology to the study of the epithelial-mesenchymal transition (EMT) and its relevance to cancer metastasis. This undertaking has been a major success, leading to a much-improved understanding of EMT itself and its connection to tumor initiation and drug resistance. But of course, new questions have a
All scientific events
Job offers
No job offers available.
All job offers