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Nuclear dynamics (UMR3664)

Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism.

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nationalities for 55 people
model systems
billion nuclei in the human body
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16 Mar
23 Mar
International Course Seminar
Epigenetics - 17th edition - From nuclear organization to metabolism and cell fate in normal state and diseases
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involving the genome and its organization will be discussed with an emphasis on technological limits and the new experimental approaches being developed today. Links between the disruption of nuclear function
18 Jan
Seminar Nuclear dynamic series
The reduced-dimensionality mechanism of homology search by RecA filament during double stranded break repair
Homologous recombination is essential for the accurate repair of double-stranded DNA breaks (DSBs). Initially, the RecBCD complex resects the ends of the DSB into 3′ single-stranded DNA on which a RecA filament assembles. Next, the filament locates the homologous repair template on the sister chromosome4. Here we directly visualize the repair of DSBs in single cells, using high-throughput mi
9 Nov
Seminar Nuclear dynamic series
H2A variants : architects and guardians of the genome
Eukaryote genomes comprises functional units such a genes, transposons and enhancers. The cues enabling the recognition and function of these units are still largely unclear. Such a role might be fulfilled by nucleosomes containing different form of cores histones H2A, H2B, H3 and H4, so called histone variants. The seminar will explore the role of histone variants in decoding the organisation of
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