CurieCoreTech Bioinformatics (CUBIC)

Activity

The Institut Curie Bioinformatics Core facility is composed of twenty bioinformaticians, biostatisticians and software engineers who offer a multidisciplinary expertise to support the biotechnological core facilities from Curie Core Tech, the research units and the hospital in their daily activities. Our skills range from data analysis, data management, software development and high-performance computing. We have five main missions: (1) knowledge and data integration, (2) collaborative support to biologists or clinicians for bioinformatics and biostatistics data analysis, (3) training in biostatistics and bioinformatics, (4) support to high-performance computing and (5) coordination of bioinformatics activities within Institut Curie.

Aims

• Bioinformatics and statistical analysis of omics and clinical data obtained from high-throughput technologies such as sequencing, single-cell profiling, mass spectrometry, or cellular phenotyping, Development, maintenance and running of bioinformatics pipelines to process data from biotechnological core facilities, including quality controls and first level analysis,
• Setting up of a seamless information system for knowledge and data sharing, data query, visualization and analysis for biomedical data,
• Support to the precision medicine program and delivery of decision-making reports in real-time for physicians in the context of clinical trials, or for routine patient management,
• Research and development for new biostatistical methods and bioinformatics tools
• Support to high-performance and scientific computing, bioinformatics pipeline optimization
• Networking

The Institut Curie Bioinformatics Core facility has conducted collaborations with virtually all units of the research center and many departments from the hospital within Institute Curie. For years, the Bioinformatics Core facility has also developed many partnerships in France and abroad (Institut Pasteur, Gustave Roussy, Mines ParisTech, INSERM, CNRS, APHP, Cancéropole, Barcelona Supercomputing Center, …) and is involved in several key national or international initiatives. To name a few, lets mention our implication in France Génomique, the Institut Français de Bioinformatique, the France Medecine Genomique 2025, Institut National du Cancer, RENABI, the SIRIC network. We are or have been involved in several European projects such as ABS4NGS, FP7 MAARS, FP7 RAIDs, H2020 ImmunAID, H2020 EUCANCan, H2020 PerMedCoe...

Services

• Bioinformatics and biostatistics data analysis, including but not limited to clinical research, epigenomics, single cell profiling, mass spectrometry, and cellular phenotyping
• Data management
• Training in bioinformatics and biostatistics
• Software engineering, scientific computing, pipeline optimization
• Access to in-house analysis software

Equipment

The Bioinformatics core facility relies on a substantial IT infrastructure, managed by the Institut Curie’s Computer team with several Petabytes of storage system, a computational cluster with several thousands of cores, along with individual customized bioinformatics workstations for each person in the group. The management of the infrastructure is ensured by the Direction of Informatics headed by Philippe Rizand.

Training

The Bioinformatics Core facility promotes the autonomous data analysis by biologists and clinicians as often as possible:

• All tools that are within biologist/clinician reach are offered through web interfaces to enable direct use by non-specialists. Training sessions are organized in collaborations with other bioinformaticians both within Institut Curie or for a wider audience, covering a large spectrum of topics such as best coding practices, statistics, biological network analysis or data analysis.
• A consulting activity is offered for people seeking advice for the bioinformatics and biostatistics analysis they carry out themselves.

platform or core facility ?

Je mettrais core facility (en plus c'est dans notre nom en anglais)