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Replication program and genome instability

DNA replication must adapt to changes in chromatin organization associated with cell differentiation and development, whose deregulation can challenge genome stability and leads to mutations, cancer and many other genetic diseases. However, despite intensive studies, the mechanisms that coordinate where and when replication initiates in the human genome remain poorly known. Our team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal replication program of the human genome and its impact on genome stability, in particular to address the following questions:


  • What determines the replication program, i.e. the position, the time of firing and the efficiency of replication origins in the human genome?
  • How this program is regulated and associated with gene transcription and chromatin organization?
  • How deregulation of these programs challenges genome stability and leads to human diseases?
Past members
Xia WU
Post-Doctoral Researcher
Sami El Hilali
Bioinformatic Scientist
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