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Unit
LUDGER JOHANNES / CHRISTOPHE LAMAZE
Cellular and Chemical Biology (UMR3666 / U1143)

The Curie Institute is a cancer research and care centre characterized by interdisciplinarity. The Cellular and Chemical Biology department cherishes this spirit by uniting within the same perimeter researchers from various backgrounds, notably organic chemistry and cell biology. It is our objective to address the timeliest challenges in life sciences and biomedicine from unique angles that become accessible due to a real integration between disciplines.

Key figures
11
awards/honours
2
ERC
21
publications with IF>20
Key publications
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News
  • manip 2
    Exploiting iron chemistry to beat cancer
    The work carried out at Institut Curie by Raphaël Rodriguez’ “Chemical Biology of Cancer” team revealed a new gateway to induce the death of cells with metastatic potential in connection with iron metabolism. Together with Marcus Conrad (Germany), the ferroptosis pioneer, and Stuart Schreiber (United States), father of modern chemical biology, they conceptualize new therapeutic approaches in an article that has just been published in the journal Molecular Cell.
    04/01/2022
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Scientific events
9 Mar
2022
Seminar
14h-23h
"Getting Closer to Dying - The Clinical Relevance of Ferroptosis and Necroptosis"
Dexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalysed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction and stroke, all of which are triggered by glutathione (GSH) depletion. GSH levels were significantly de
2 Feb
2022
Seminar
10h-23h
Seminar: "Ferroptosis: From basic mechanisms to therapeutic opportunities"
L’Institut Curie et le Pr Alain Puisieux, directeur du Centre de recherche, auront l’honneur d’accueillir le pionnier de la ferroptose, Marcus Conrad (Institute of Metabolism and Cell Death, Germany) le mercredi 2 février dans le cadre d’un séminaire sur ce thème : « From basic mechanisms to therapeutic opportunities ».
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Job offers
  • Postdoctoral Position in CRYO-ELECTRON MICROSCOPY OF MEMBRANE PROTEINS (M/F)
    Institut Curie Research Center
    Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Research Center is to develop basic research and to use this knowledge to improve the diagnosis, prognosis, and therapeutics of cancer as part of the continuum between basic research and innovation serving the patient.

    Leibniz-Institute for Molecular Pharmacology (FMP)
    The FMP is a non-university research institute and member of the Leibniz Association. The institute conducts basic research in molecular pharmacology and provides a vibrant, international and collaborative environment with state-of-the-art research facilities. The FMP belongs to the “Forschungsverbund Berlin e. V. (FVB)”, an institution of seven natural sciences research institutes in Berlin.
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