The Curie Institute is a cancer research and care centre characterized by interdisciplinarity. The Cellular and Chemical Biology department cherishes this spirit by uniting within the same perimeter researchers from various backgrounds, notably organic chemistry and cell biology. It is our objective to address the timeliest challenges in life sciences and biomedicine from unique angles that become accessible due to a real integration between disciplines.
Inflammation and cancer: identifying the role of copper paves the way for new therapeutic applicationsFor the 1st time, researchers from Institut Curie, the CNRS and Inserm have uncovered a previously unknown chain of biochemical reactions. This chain involves copper and leads to metabolic and epigenetic alterations that activate inflammation and tumorigenesis. But there is more; the research team developed a “drug prototype” capable of mitigating both the mechanisms of inflammation and the processes potentially involved in metastatic spread. These results were published in the journal Nature on April 26, 2023.26/04/2023
The secret of an essential cell signaling pathway has finally been revealedA membrane receptor is like a lock, a ligand is like a key and when one binds to the other, cell activity is triggered. Although this relatively simple pattern often works, a team at Institut Curie has just revealed in Nature Cell Biology that it is not always as simple as that: for the JAK-STAT signaling pathway, vital in several pathologies, it all happens in the endosome.01/03/2023
A glittering cast for the 3rd symposium dedicated to Chemical BiologyThe 3rd international symposium dedicated to Chemical Biology was held last January 12th and 13th at Institut Curie. The 2023 edition drew a prestigious crowd, with world reknowed speakers.18/01/2023
TEMTIA conference: understanding and targeting EMT to fight metastasesFor its 10th edition, the TEMTIA conference is coming to France for the very first time, taking place at Institut Curie from November 7 to 10. For the event, the two co-chairs of TEMTIA, Prof. Alain Puisieux, Director of the Institut Curie Research Center and Pierre Savagner, Inserm researcher at Gustave Roussy, take a closer look at the challenges surrounding molecular and cellular aspects of the epithelial–mesenchymal transition (EMT) at the root of metastatic cancer progression.09/11/2022
Therapeutic chemistry: Raphaël Rodriguez, winner of the prestigious Klaus Grohe prize 2022The Klaus Grohe foundation, a member of the German Chemical Society, awards its Klaus Grohe prize 2022 to Raphaël Rodriguez, CNRS research director and team leader at Institut Curie, for his pioneering work at the crossroads of chemistry and biology.23/09/2022
A new type of drug that kills therapy-resistant pancreatic cancer cellsInactive when administered, “prodrugs” become bioactive following a chemical reaction inside a cell or the organism. The “Chemical Biology” team at Institut Curie, headed by Raphaël Rodriguez, just revealed the efficacy of prodrugs on pancreatic cancer cells with metastatic potential, resistant to conventional treatment.05/07/2022
An international meeting organized by Institut Curie, Chimie PSL University, Sorbonne University, Inserm and CNRS.
For the 3rd PSL Chemical Biology Symposium, the state of the art in chemical biology will again be presented by world leaders to feature the latest innovations and
More information to come.
Ingénieur de recherche - Synthèse Chimique / Chemobiologie (H/F)Le Centre de recherche de l’Institut Curie
L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est constitué d'un hôpital et d'un Centre de recherche de plus de 1000 collaborateurs avec une forte représentativité internationale.
L’objectif du Centre de recherche de l’institut Curie est de développer la recherche fondamentale et d’utiliser les connaissances produites pour améliorer le diagnostic, le pronostic, la thérapeutique des cancers dans le cadre du continuum entre la recherche fondamentale et l’innovation au service du malade.