Unit
Cellular and Chemical Biology (UMR3666 / U1143)
Thematic areas of research:
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LUDGER JOHANNES / CHRISTOPHE LAMAZE
Cellular and Chemical Biology (UMR3666 / U1143)
The Curie Institute is a cancer research and care centre characterized by interdisciplinarity. The Cellular and Chemical Biology department cherishes this spirit by uniting within the same perimeter researchers from various backgrounds, notably organic chemistry and cell biology. It is our objective to address the timeliest challenges in life sciences and biomedicine from unique angles that become accessible due to a real integration between disciplines.
Teams
Key figures
11
awards/honours
2
ERC
21
publications with IF>20
Key publications
All publications
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Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytesCommunications Biology
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CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumorsJournal for ImmunoTherapy of Cancer
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CD44 regulates epigenetic plasticity by mediating iron endocytosisNature Chemistry
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Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2Nature Chemical Biology
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News
All news
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Inflammation and cancer: identifying the role of copper paves the way for new therapeutic applicationsFor the 1st time, researchers from Institut Curie, the CNRS and Inserm have uncovered a previously unknown chain of biochemical reactions. This chain involves copper and leads to metabolic and epigenetic alterations that activate inflammation and tumorigenesis. But there is more; the research team developed a “drug prototype” capable of mitigating both the mechanisms of inflammation and the processes potentially involved in metastatic spread. These results were published in the journal Nature on April 26, 2023.26/04/2023 -
The secret of an essential cell signaling pathway has finally been revealedA membrane receptor is like a lock, a ligand is like a key and when one binds to the other, cell activity is triggered. Although this relatively simple pattern often works, a team at Institut Curie has just revealed in Nature Cell Biology that it is not always as simple as that: for the JAK-STAT signaling pathway, vital in several pathologies, it all happens in the endosome.01/03/2023 -
A glittering cast for the 3rd symposium dedicated to Chemical BiologyThe 3rd international symposium dedicated to Chemical Biology was held last January 12th and 13th at Institut Curie. The 2023 edition drew a prestigious crowd, with world reknowed speakers.18/01/2023 -
TEMTIA conference: understanding and targeting EMT to fight metastasesFor its 10th edition, the TEMTIA conference is coming to France for the very first time, taking place at Institut Curie from November 7 to 10. For the event, the two co-chairs of TEMTIA, Prof. Alain Puisieux, Director of the Institut Curie Research Center and Pierre Savagner, Inserm researcher at Gustave Roussy, take a closer look at the challenges surrounding molecular and cellular aspects of the epithelial–mesenchymal transition (EMT) at the root of metastatic cancer progression.09/11/2022 -
Therapeutic chemistry: Raphaël Rodriguez, winner of the prestigious Klaus Grohe prize 2022The Klaus Grohe foundation, a member of the German Chemical Society, awards its Klaus Grohe prize 2022 to Raphaël Rodriguez, CNRS research director and team leader at Institut Curie, for his pioneering work at the crossroads of chemistry and biology.23/09/2022 -
A new type of drug that kills therapy-resistant pancreatic cancer cellsInactive when administered, “prodrugs” become bioactive following a chemical reaction inside a cell or the organism. The “Chemical Biology” team at Institut Curie, headed by Raphaël Rodriguez, just revealed the efficacy of prodrugs on pancreatic cancer cells with metastatic potential, resistant to conventional treatment.05/07/2022
Scientific events
All scientific events
28 Apr
2023
Seminar
11h-23h
Modern fluorophores and hypoxia targeting
Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors. It elicits responses from these biological systems that impact their survival, for example, hypoxia makes tumors more resistant to all forms of therapy and leads to poor patient prognosis. Furthermore, hypoxia in the tumor microenvironment is heterogeneous (with O2 ranging
12 Jan
2023
13 Jan
2023
Event
08h-19h
3rd PSL Chemical Biology Symposium
The 3rd PSL Chemical Biology symposium will take place in Paris at Institut Curie, from January 12-13, 2023.
An international meeting organized by Institut Curie, Chimie PSL University, Sorbonne University, Inserm and CNRS.
For the 3rd PSL Chemical Biology Symposium, the state of the art in chemical biology will again be presented by world leaders to feature the latest innovations and
An international meeting organized by Institut Curie, Chimie PSL University, Sorbonne University, Inserm and CNRS.
For the 3rd PSL Chemical Biology Symposium, the state of the art in chemical biology will again be presented by world leaders to feature the latest innovations and
9 Sep
2022
Seminar
10h-23h
Targeting chromatin regulators in cancer
A hallmark of all malignancies is transcriptional dysregulation, which is initiated by recurrent translocations and/or mutations in transcription factors and chromatin regulators. These genetic aberrations manifests as a block in differentiation and an increase in malignant self-renewal. They also facilitate the cancer’s ability to adapt rapidly to therapeutic pressure. These established fea
7 Jun
2022
9 Jun
2022
Symposium
09h-18h
4TH SUNRise MEETING
The 4th edition SUNRise Meeting will be held from 7th to 9th June 2022 at INSTITUT CURIE - Paris.
More information to come.
More information to come.
25 May
2022
Seminar
11h-23h
Imaging tumor initiation and progression in live animals at cellular and sub-cellular resolution
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