The Mechanics and Genetics of Embryonic and Tumour Development team studies the role of mechanical strain and deformation of macroscopic biological structures at the cell or multi-cellular scale, into the regulation and the generation of active biochemical processes at the microscopic molecular scale, including gene expression, in vivo. The group focuses on the coupling between mechanical strains and biochemical signalling in developmental and cancer biology.
The team also concentrates on the evolutionary emergence of the morphological and biochemical patterns at the origin of the first metazoans over 600 million years ago. The experimental results of the team indicate it as a as a mechanotransductive primitive behaviorial feeding response of pre-metazoa multi-cellular colonies to environmental marine flow hydrodynamic strains.
Marine flow leading to formation of the primitive gutThe formation of the primitive gut occurred via mechanotransduction, generated by marine flow in which the first animal organisms developed over 700 million years ago. This is the surprising conclusion of Emmanuel Farge and his team, Mechanics and genetics of embryonic and tumor development (CNRS UMR168 / Sorbonne University), who looked at the origins of the formation of this organ.23/12/2022
Cancer under pressureA team of Institut Curie researchers has conducted in-depth exploration of the mechanisms linking mechanical pressure and carcinogenesis. They discovered a key protein, a potential therapeutic target against a number of cancers. This work has been published in the journal Communications Biology.31/03/2022